Electromechanics of cartilage: surface mapping, instrumentation/software development, structure/function relationships

软骨机电：表面测绘、仪器/软件开发、结构/功能关系

• 批准号: 445265-2012
• 负责人: Buschmann, Michael
• 金额: $ 8.74万
• 依托单位: École Polytechnique de Montréal
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=554156
• 关键词: Electromechanics; cartilage; surface; mapping; instrumentation

Articular cartilage is the white tissue covering the ends of bones allowing for joint motion and loading in daily activities. It has no nerves and no natural capacity to heal so that injury and disease of cartilage generally progresses until it is worn down to expose bone and cause pain and Arthritis. The current lack of treatments for Arthritis and cartilage disease is largely due to our inability to accurately and sensitively monitor cartilage changes in early stages of degeneration where treatments may effectively intervene. Current clinical diagnostic tools for cartilage are insufficient in terms of sensitivity and specificity and predictive value for disease progression.

关节软骨是覆盖在骨骼末端的白色组织，允许在日常活动中进行关节运动和负荷。它没有神经，也没有自然的愈合能力，因此软骨的损伤和疾病通常会继续发展，直到它被磨损，露出骨头，引起疼痛和关节炎。目前缺乏对关节炎和软骨疾病的治疗，这在很大程度上是因为我们无法准确和敏感地监测软骨退变早期的变化，而治疗可能会有效地干预。目前对软骨的临床诊断工具在敏感性和特异性以及对疾病进展的预测价值方面是不够的。