Control of Campylobacter jejuni in chickens by vaccination

空肠弯曲菌是一种主要的食源性致病菌。2004年，加拿大报告了9，000例人类凸轮杆菌病，而同年有5，000例沙门氏菌病。据估计，美国每年用于人类弯曲杆菌病的费用超过80亿美元。在大多数情况下，家禽产品是感染源，因为鸡感染弯曲杆菌，可以在没有任何临床症状的情况下排出这种微生物。因此，为了降低这种微生物的风险，减少家禽产品中的弯曲杆菌负担至关重要。在这里，我们建议进行一系列的研究，以评估天然免疫刺激剂的能力，以减少鸡弯曲杆菌的负担。我们还打算使用上述免疫刺激剂开发新的疫苗制剂，以保护鸡免受弯曲杆菌感染。最后，我们将研究疫苗和益生菌之间可能的协同作用，以改善对这种细菌的控制。我们的研究结果将最终为控制弯曲杆菌及其向人类的传播提供一种手段。

Campylobacter jejuni is a major food-borne pathogen. In 2004, there were 9,000 reported cases of human camplylobacteriosis in Canada, compared to 5,000 cases of salmonellosis during the same year. According to some estimates, the annual cost of human campylobacteriosis in the US is over 8 billion dollars. Poultry products are the source of infection in most cases, because chickens become infected with Campylobacter and can shed this microbe without showing any clinical signs. Therefore, to reduce the risk of this microbe, it is critically important to reduce the Campylobacter burden in poultry products. Here, we propose to undertake a series of studies to evaluate the ability of natural immune stimulants to reduce burden of Campylobacter in chickens. We also intend to develop novel vaccine formulation using the above immune stimulants to confer protection against Campyobacter in chickens. Finally, we will investigate the possible synergism between vaccines and probiotics for improved control of this bacterium. The results of our studies will ultimately provide a means for control of Campylobacter and its transmission to humans.