Development of a stilbene-enriched icewine grape skin extract

酿酒葡萄是白藜芦醇和各种对健康有益的相关分子的天然来源。这种分子的主要基团之一被称为二苯乙烯。这些有益分子主要是在葡萄皮中产生的。在整个秋季，葡萄中的二苯乙烯类物质会大量积累。此外，研究人员还表明，通过将葡萄暴露在紫外光下，可以在收获后刺激葡萄产生更多的这些分子。葡萄皮是冰酒生产中的废品。不仅因为目前没有与葡萄皮相关的价值，而且暴露它们也是昂贵的。鉴于葡萄皮可能是二苯乙烯类化合物的最佳天然来源，我们建议通过从葡萄皮下脚料中提取二苯乙烯类化合物来提取价值。从秋季收获的冰酒葡萄开始，我们将使用反复紫外线刺激的方案来提高二苯乙烯类化合物的产量。然后我们将从葡萄肉中分离出果皮。葡萄浆可用于酿酒。在这里，我们将专注于开发一种从皮肤中最大限度地提取二苯乙烯类化合物的方法。然后我们将验证提取的二苯乙烯类化合物的生物活性。我们预计这项工作将从冰酒葡萄中产生一种新的产品(或产品系列)，这样生产葡萄酒的葡萄浆不会受到不利影响(实际上，它也将得到增强)，并从目前属于废物的果皮中获得显著价值。这将反过来在加工、包装和销售我们从冰酒葡萄中提取的富含二苯乙烯的新产品方面带来新的工作岗位。

Wine grapes are a natural source of resveratrol and a variety of related molecules with health benefits. One of the main groups of such molecules is called stilbenes. These beneficial molecules are produced primarily in grape skins. Over the course of the fall season there is an accumulation of stilbenes in grapes. In addition, researchers have shown that grapes can be stimulated post-harvest to produce even more of these molecules by exposing the grapes to UV light. Grape skins are a waste product in ice wine production. Not only is there no value currently associated with the grape skins, but it is also expensive to expose of them. Given that the skins are probably the best natural source of stilbenes, we propose to extract value from the grape skin waste product by extracting the stilbenes from them. Starting with fall harvest ice wine grapes, we will use a protocol of repeated UV stimulation to enhance production of stilbenes. We will then separate skins from the grape pulp. Grape pulp can be used in wine production. Here we will focus on developing a method to maximally extract stilbenes from the skins. We will then verify the biological activities of the extracted stilbenes. We expect this work to lead to a new product (or line of products) from ice wine grapes, such that the wine-producing grape pulp is not adversely affected (indeed, it will also be stilbene-enhanced) and significant value is captured from the skins, which are currently a waste product. This will in turn lead to new jobs in processing, packaging and selling our new stilbene-rich products from ice wine grapes.