Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media

多重散射非均匀双折射介质中的偏振穆勒矩阵成像

• 批准号: 194509-2013
• 负责人: Vitkin, Alex
• 金额: $ 2.99万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=569791
• 关键词: Polarimetric; Mueller; matrix; imaging; multiply

Light provides us with much useful information about our surroundings. In addition to its wavelength (colour) and intensity, another useful property of an optical beam is its polarization state, or the orientation of the electric field vector perpendicular to the propagation direction. When light interacts with an object, its polarization state will be changed. Hence the properties of the object can be obtained by measuring this change. Here, we propose to extend our research into polarized light interactions with turbid materials. The long-term goal of the research is to perform polarized light assessment of biological tissues. The numerous deflections experienced by the light in such materials will significantly scramble its polarization. However, we and others have shown that a surprising amount of useful polarization information can be still retained upon such multiple scattering. The proposed methodology will thus optimize measurements and analysis of polarization effects in turbid media. These methods can then be used to characterize turbid systems such as planetary atmospheres, biological tissues, or amorphous semiconductors. It is also proposed to investigate the effects of the medium "birefringence". This refers to the structural asymmetry / microarchitectural organization of some materials, which causes them to interact with polarized light in distinctive ways. Polarization measurements have long been used in TRANSPARENT media or thin materials (thin films) to probe the details of its structure. The proposed work is novel in its intent to quantify these structural asymmetries in optically thick TURBID media. Significance in the biomedical arena stems from the asymmetric nature of many biological tissues, and microstructural rearrangements as a result of disease progression or treatments. Our polarized light approach can then report on tissue functional status and tissue viability in urology (bladder wall anisotropy, structure-function relationship in obstructed bladder disease), cardiology (heart muscle remodelling following infarct and stem-cell regenerative therapies) and oncology (breast cancer metastatic spread along anisotropic routes in the tumour extracellular matrix).

光为我们提供了许多关于我们周围环境的有用信息。除了它的波长（颜色）和强度，光束的另一个有用的属性是它的偏振状态，或垂直于传播方向的电场矢量的方向。当光与物体相互作用时，其偏振态将发生变化。因此，物体的性质可以通过测量这种变化来获得。在这里，我们建议将我们的研究扩展到偏振光与混浊材料的相互作用。该研究的长期目标是对生物组织进行偏振光评估。光在这种材料中经历的许多偏转将显著地扰乱其偏振。然而，我们和其他人已经表明，一个令人惊讶的数量的有用的偏振信息仍然可以保留在这样的多次散射。因此，所提出的方法将优化测量和分析混浊介质中的偏振效应。然后，这些方法可以用来表征混浊系统，如行星大气，生物组织，或非晶半导体。它还建议调查的影响，介质的“双折射”。 这是指某些材料的结构不对称/微结构组织，这导致它们以独特的方式与偏振光相互作用。偏振测量长期以来一直用于透明介质或薄材料（薄膜），以探测其结构的细节。拟议的工作是新颖的，其目的是量化这些结构不对称的光学厚TURBID介质。 在生物医学竞技场中的重要性源于许多生物组织的不对称性质，以及疾病进展或治疗导致的微结构重排。 我们的偏振光方法可以报告泌尿科（膀胱壁各向异性，梗阻性膀胱疾病的结构-功能关系），心脏科（心肌梗死和干细胞再生治疗后的心肌重塑）和肿瘤学（乳腺癌转移性扩散沿着肿瘤细胞外基质的各向异性路线）的组织功能状态和组织活力。