Polarized light assessment of multiply scattering heterogenous birefringent media
多重散射异质双折射介质的偏振光评估
基本信息
- 批准号:RGPIN-2018-04930
- 负责人:
- 金额:$ 7.29万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Light provides us with much useful information about our surroundings. In addition to its wavelength (colour) and intensity, another useful property of an optical beam is its polarization state, or the orientation of the electric field vector perpendicular to the propagation direction. When light interacts with an object, its polarization state will be changed. Hence the properties of the object can be obtained by measuring this change.Polarization measurements have long been used in TRANSPARENT media or thin materials (thin films) to probe the details of their structure and composition. The proposed work is novel in its use of polarized light for quantifying optically thick TURBID media. The numerous deflections experienced by the light in such materials will significantly scramble its polarization. However, we and others have shown that a surprising amount of useful polarization information can still be retained even after a significant number of (multiple) scattering events. Sensitive measurement and accurate quantification of this surviving polarization signal then yields unique characteristics and "signatures" of the interrogated material. The proposed methodology will thus further optimize measurements and analysis of polarization effects in such interesting but technically challenging turbid media. The long-term goal of the research is to perform accurate polarized light assessment of biological tissues. Although not explicitly pursued here, the developed polarized methods may also find applications in non-biological domains such as remote sensing of turbulent flows and planetary atmospheres, underwater characterization of objects, and inspection in harsh (e.g., radiation damage) environments. The proposed scientific and technical developments will thus (1) optimize polarimetric imaging methods as a rapid guidance technology for accurate assessment of tissue pathology (e.g., tumour margin detection via polarimetrically-guided mass spectrometry during cancer surgery), (2) report on tissue functional status and viability in difficult-to-reach body locations (e.g., inside of the bladder wall in urology), and (3) enable further understanding of linear and non-linear polarized light turbid media (biological tissue) interactions for improved tissue microscopy. Overall, this research program will further advance the promising optical technology based on the unique strengths and information content of polarized light, towards enabling a variety of exciting and important biomedical applications.
光为我们提供了许多有关周围环境的有用信息。除了波长(颜色)和强度之外,光束的另一个有用属性是其偏振态,或垂直于传播方向的电场矢量的方向。当光与物体相互作用时,其偏振态会发生改变。因此,可以通过测量这种变化来获得物体的属性。偏振测量长期以来一直用于透明介质或薄材料(薄膜),以探测其结构和成分的细节。这项工作的新颖之处在于它使用偏振光来量化光学厚的浑浊介质。光在此类材料中经历的多次偏转将显着扰乱其偏振。然而,我们和其他人已经证明,即使在大量(多次)散射事件之后,仍然可以保留数量惊人的有用偏振信息。然后,对残留的偏振信号进行灵敏测量和准确量化,即可产生被询问材料的独特特征和“签名”。 因此,所提出的方法将进一步优化这种有趣但技术上具有挑战性的浑浊介质中偏振效应的测量和分析。该研究的长期目标是对生物组织进行准确的偏振光评估。尽管这里没有明确追求,但所开发的偏振方法也可以在非生物领域找到应用,例如湍流和行星大气的遥感、物体的水下特征以及恶劣(例如辐射损伤)环境中的检查。 因此,拟议的科学和技术发展将(1)优化偏振成像方法,作为准确评估组织病理学的快速指导技术(例如,在癌症手术期间通过偏振引导质谱法检测肿瘤边缘),(2)报告难以到达的身体位置(例如,泌尿科膀胱壁内部)的组织功能状态和活力,以及(3)能够进一步了解 线性和非线性偏振光混浊介质(生物组织)相互作用,以改进组织显微镜检查。 总体而言,该研究计划将进一步推进基于偏振光独特优势和信息内容的有前途的光学技术,以实现各种令人兴奋和重要的生物医学应用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vitkin, Alex其他文献
Hybrid method of strain estimation in optical coherence elastography using combined sub-wavelength phase measurements and supra-pixel displacement tracking
- DOI:
10.1002/jbio.201500203 - 发表时间:
2016-05-01 - 期刊:
- 影响因子:2.8
- 作者:
Zaitsev, Vladimir Y.;Matveyev, Alexander L.;Vitkin, Alex - 通讯作者:
Vitkin, Alex
A multiscale Mueller polarimetry module for a stereo zoom microscope
- DOI:
10.1007/s13534-019-00116-w - 发表时间:
2019-08-01 - 期刊:
- 影响因子:4.6
- 作者:
Gribble, Adam;Pinkert, Michael A.;Vitkin, Alex - 通讯作者:
Vitkin, Alex
Mueller matrix polarization parameters correlate with local recurrence in patients with stage III colorectal cancer.
- DOI:
10.1038/s41598-023-40480-3 - 发表时间:
2023-08-17 - 期刊:
- 影响因子:4.6
- 作者:
Tumanova, Kseniia;Serra, Stefano;Majumdar, Anamitra;Lad, Jigar;Quereshy, Fayez;Khorasani, Mohammadali;Vitkin, Alex - 通讯作者:
Vitkin, Alex
Peri-tumoural stroma collagen organization of invasive ductal carcinoma assessed by polarized light microscopy differs between OncotypeDX risk group
- DOI:
10.1002/jbio.202000188 - 发表时间:
2020-08-10 - 期刊:
- 影响因子:2.8
- 作者:
Jones, Blake;Thomas, Georgia;Vitkin, Alex - 通讯作者:
Vitkin, Alex
Speckle statistics in OCT images: Monte Carlo simulations and experimental studies
- DOI:
10.1364/ol.39.003472 - 发表时间:
2014-06-15 - 期刊:
- 影响因子:3.6
- 作者:
Kirillin, Mikhail Yu.;Farhat, Golnaz;Vitkin, Alex - 通讯作者:
Vitkin, Alex
Vitkin, Alex的其他文献
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{{ truncateString('Vitkin, Alex', 18)}}的其他基金
Polarized light assessment of multiply scattering heterogenous birefringent media
多重散射异质双折射介质的偏振光评估
- 批准号:
RGPIN-2018-04930 - 财政年份:2021
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarized light assessment of multiply scattering heterogenous birefringent media
多重散射异质双折射介质的偏振光评估
- 批准号:
RGPIN-2018-04930 - 财政年份:2020
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarized light assessment of multiply scattering heterogenous birefringent media
多重散射异质双折射介质的偏振光评估
- 批准号:
RGPIN-2018-04930 - 财政年份:2019
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarized light assessment of multiply scattering heterogenous birefringent media
多重散射异质双折射介质的偏振光评估
- 批准号:
RGPIN-2018-04930 - 财政年份:2018
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media
多重散射非均匀双折射介质中的偏振穆勒矩阵成像
- 批准号:
194509-2013 - 财政年份:2017
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media
多重散射非均匀双折射介质中的偏振穆勒矩阵成像
- 批准号:
194509-2013 - 财政年份:2016
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media
多重散射非均匀双折射介质中的偏振穆勒矩阵成像
- 批准号:
194509-2013 - 财政年份:2015
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media
多重散射非均匀双折射介质中的偏振穆勒矩阵成像
- 批准号:
194509-2013 - 财政年份:2014
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Polarimetric Mueller matrix imaging in multiply scattering inhomogeneous birefringent media
多重散射非均匀双折射介质中的偏振穆勒矩阵成像
- 批准号:
194509-2013 - 财政年份:2013
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
Spectral polarimetry in multiply scattering birefringent optically active media
多重散射双折射光学活性介质中的光谱偏振测定
- 批准号:
194509-2007 - 财政年份:2012
- 资助金额:
$ 7.29万 - 项目类别:
Discovery Grants Program - Individual
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