Mechanisms of ion and acid-base regulation in aquatic animals

水生动物离子和酸碱调节机制

• 批准号: 203736-2011
• 负责人: Goss, Greg
• 金额: $ 4.74万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=570000
• 关键词: Mechanisms; ion; acid; base; regulation

The long-term focus of the research program is to identify and characterize ion transport systems involved in the normal functional physiology in animals. Regulation of ion and acid-base status is absolutely essential for proper cell function and metabolism and is also an integral component of adaptability to different environments. Furthermore, disorders of ion and acid-base metabolism are linked to numerous animal pathologies. Understanding the molecular mechanisms and regulation of these ion and acid-base transport system evolution will enable us to understand and predict physiological adaptability to environmental change (changes in pH, salinity, temperature) or various environmental stressors such as toxicants (e.g. waterborne metals, pollutants, organic matter). I use a variety of model systems to investigate these processes and examine the regulation and control of ion and acid-base transporters. My research program uses both freshwater animals (fish, crabs, mosquitoes) and seawater animals (dogfish, hagfish, crabs, sponges) through research conducted in both Alberta and at Bamfield Marine Sciences Centre. The overarching goal of the research program is to understanding both the common and unique methods of ion and acid-base transport and its regulation.

该研究计划的长期重点是确定和表征参与动物正常功能生理的离子转运系统。离子和酸碱状态的调节对于正常的细胞功能和代谢是绝对必要的，也是适应不同环境的一个组成部分。此外，离子和酸碱代谢紊乱与许多动物病理学有关。了解这些离子和酸碱转运系统进化的分子机制和调控将使我们能够理解和预测生理适应环境变化（pH值，盐度，温度）或各种环境应激源，如有毒物质（例如水生金属，污染物，有机物）。我使用各种模型系统来研究这些过程，并检查离子和酸碱转运蛋白的调节和控制。 我的研究计划使用淡水动物（鱼，螃蟹，蚊子）和海水动物（角鲨，盲鳗，螃蟹，海绵）通过在阿尔伯塔和班菲尔德海洋科学中心进行的研究。 该研究计划的总体目标是了解离子和酸碱转运及其调节的常见和独特方法。