Supramolecular assistance of imidazolium salts in Organic/Bioorganic Catalysis and Organized Materials

功能性咪唑基超分子结构的研究为化学带来了新的机遇，同时也弥合了有机和超分子体系之间的差距，以充分理解用于在不同层次中组装这些单元的驱动力。咪唑阳离子是本提案中描述的三个项目共同的关键组成部分，包括一个跨越有机，生物有机和材料化学学科的研究计划。超分子组装需要构建和操纵纳米尺寸的复杂分子结构。 我们使用咪唑盐作为离子液体（IL）的过渡金属催化，一个领域的强烈电流感兴趣的广泛的反应。 有机金属化合物在离子液体中的溶解度增加，有利于它们在均相催化中的使用，因此通常上级普通有机溶剂。我们还专注于这些咪唑盐的物理化学性质，其中两个可以强调：（i）类卡宾物种的形成;和（ii）通过静电，H-键和/或芳族堆积相互作用形成的“超分子”。最后一种性质用于通过在不同客体（反应性物种）和这些阳离子受体之间形成“超分子复合物”来改变分子反应性。 我们也有兴趣研究新合成的咪唑啉金属配合物的大环分子的存在下，以及在囊泡和细胞膜中操作的合成咪唑啉为基础的阴离子转运系统的发展，用于医药应用。

The study of functional imidazolium-based supramolecular architectures gives rise to emerging opportunities in chemistry, but also bridges the gap between organic and supramolecular systems in an effort to fully understand the driving forces used to assemble these units in different hierarchies. Imidazolium cation is a critical building block common to the three projects described in this proposal, comprising a research program that spans the disciplines of organic, bioorganic and materials chemistry. Supramolecular assemblies require the construction and manipulation of complex molecular architectures of nanometer-sized dimensions. We use imidazolium salts as ionic liquids (IL) for transition metal catalysis, an area of intense current interest for a wide range of reactions. Solubility of organometallic compounds increases in ILs favouring their use in homogeneous catalysis, and thus are often superior to common organic solvents. We also focus on the physico-chemical properties of these imidazolium salts, two of which that can be highlighted: (i) the formation of carbenoid species; and (ii) the formation of "supramolecules" via electrostatic, H-bonds and/or aromatic stacking interactions. The last property is used to modify the molecular reactivity by the formation of "supramolecular complexes" between different guests (reactive species) and these cationic receptors. We are also interested to study newly synthesized imidazolium-metal complexes for medicinal applications in the presence of macrocyclic molecules, as well as the development of synthetic imidazolium-based anion transport systems that operate in vesicle and cell membranes.