Chemical and biochemical approaches for the design of functional supramolecular systems

用于设计功能性超分子系统的化学和生物化学方法

• 批准号: RGPIN-2016-03866
• 负责人: Schmitzer, Andreea
• 金额: $ 4.44万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632829
• 关键词: Chemical; biochemical; approaches; design; functional

To achieve the best energy, time and catalytic performance of biological systems, nature has developed remarkable strategies that rely on self-assembly, structural hierarchy and synergetic properties of individual structural components. These strategies motivate us to conduct bio-inspired research to create molecules and strategies that follow biological examples for specific applications. Our research program aims the fundamental understanding of the underlying mechanisms in the self-assembly of functional systems towards two specific themes: 1) anion transporters to target cell membranes and 2) non covalent interactions in catalysis. These strategies will be used to generate smart supramolecular systems based on our strong expertise in self-assembly, transmembrane transport, organic and bio-organic areas.

为了实现生物系统的最佳能量、时间和催化性能，自然界已经开发出依赖于单个结构组件的自组装、结构层次和协同特性的显着策略。这些策略促使我们进行生物启发的研究，以创建遵循特定应用生物学实例的分子和策略。我们的研究计划旨在对功能系统自组装的基本机制进行基本了解，以实现两个特定主题：1）靶细胞膜的阴离子转运蛋白和2）催化中的非共价相互作用。基于我们在自组装、跨膜转运、有机和生物有机领域的强大专业知识，这些策略将用于生成智能超分子系统。