Central and peripheral mechanisms contributing to human balance control

有助于人体平衡控制的中枢和外围机制

• 批准号: 326910-2011
• 负责人: Carpenter, Mark
• 金额: $ 2.91万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571870
• 关键词: Central; peripheral; mechanisms; contributing; human

We have all seen the effect that fear, anxiety and confidence can have on the ability to control balance. Just think of someone trying to walk across a balance beam. If the beam is on the ground, most people usually have no difficulty to walk across it; however, if it is raised high in the air, people are likely to lose their balance and fall. Interestingly, the only thing that has changed in those two conditions is the threat or consequence of a fall. The emotional response to the threat of falling is one factor that we believe may contribute to balance problems and falls in older adults and people with balance disorders. Our research has shown that increased threat and arousal in otherwise healthy individuals can directly influence the way they control balance. However, the specific way in which threat influences the brain's ability to control balance is currently unknown. Therefore, the short term goal of the research program is to understand how threat influences dynamic balance responses, and may influence the way the brain receives and processes sensory information relevant to controlling balance. This research is part of my long term goal to understand how the brain, sensory systems and muscles contribute to healthy and pathological balance. We will manipulate threat by having subjects perform balance tasks while standing on a physical, or virtual (using 3D virtual reality), platform that can be raised to different heights. A series of studies will be performed to assess how threat influences our ability to respond to unexpected balance disturbances and discover how threat influences sensory systems responsible for detecting movement of the body and head. Balance performance will be assessed from ground-reaction forces, motion analysis and muscular activity recorded during quiet standing and balance perturbations. Knowledge developed from the proposed research program will be used to identify the specific neural mechanisms that are involved in threat-related changes in human balance control and will improve our understanding of how links between emotion and balance may contribute to balance deficits and falls.

我们都看到了恐惧、焦虑和自信对控制平衡能力的影响。想象一下有人试图走过平衡木。如果横梁在地面上，大多数人通常没有困难走过它;然而，如果它被高高地举在空中，人们很可能失去平衡而摔倒。有趣的是，在这两种情况下，唯一改变的是跌倒的威胁或后果。对跌倒威胁的情绪反应是我们认为可能导致老年人和平衡障碍患者平衡问题和福尔斯跌倒的一个因素。我们的研究表明，在其他健康的个体中，威胁和唤醒的增加会直接影响他们控制平衡的方式。然而，威胁影响大脑控制平衡能力的具体方式目前尚不清楚。因此，研究计划的短期目标是了解威胁如何影响动态平衡反应，并可能影响大脑接收和处理与控制平衡相关的感官信息的方式。这项研究是我的长期目标的一部分，以了解大脑，感觉系统和肌肉如何有助于健康和病理平衡。我们将通过让受试者站在可以提升到不同高度的物理或虚拟（使用3D虚拟现实）平台上执行平衡任务来操纵威胁。将进行一系列研究，以评估威胁如何影响我们应对意外平衡干扰的能力，并发现威胁如何影响负责检测身体和头部运动的感觉系统。平衡性能将通过地面反作用力、运动分析和安静站立和平衡扰动期间记录的肌肉活动进行评估。从拟议的研究计划中开发的知识将用于识别与人类平衡控制的威胁相关变化有关的特定神经机制，并将提高我们对情绪和平衡之间的联系如何导致平衡缺陷和福尔斯的理解。