Fruit flavanoids: structure modification, antioxidant properties and mode of action in food and biological model systems

水果黄酮类化合物：食品和生物模型系统中的结构修饰、抗氧化特性和作用方式

• 批准号: 327056-2011
• 负责人: Rupasinghe, Vasantha
• 金额: $ 2.26万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571906
• 关键词: Fruit; flavanoids; structure; modification; antioxidant

Canada has a sustainable supply of agricultural bio-resources, which include not only diverse agricultural commodities but also under-utilized bio-waste generated through agricultural production and processing. The World Health Organization has highlighted a changing world disease profile. In North America, significant challenges are being faced from oxidative stress-linked chronic disease epidemics, which are directly or indirectly linked to diet and the environment. Therefore, chemoprevention through diet modification, i.e. increased consumption of fruits and vegetables as well as the use of novel food ingredients derived from fruits and vegetables, will be important in helping to manage the current and emerging health care challenges. Natural plant compounds with antioxidant and cell signaling modulating properties, such as polyphenolics, triterpenes, and carotenoids, are now widely thought by the scientific community to be the principle components in fruits that provide specific health benefits beyond the basic nutritional functions. The proposed research will investigate the functionality of selected fruit compounds that can be efficiently extracted from under-utilized fruits in Canada. The proposed research will fill knowledge gaps in understanding of the biological functionality and industrial uses of unique bioactives present in cool climate fruits, fruit processing by-products and orchard wastes; the mode of action of selected bioactive compounds and their derivatives; and effect of food processing. Food model systems of omega-3 polyunsaturated fatty acids (PUFA) will be used to assess fruit bioactives as natural stabilizers of PUFA lipids. The bioavailability and biological functionality of fruit bioactives and their new derivatives will be studied using selected animal research model systems with the aim of developing functional food ingredients and nutraceuticals targeted at selected oxidative stress-medicated chronic diseases. The long-term scope of the research is to develop and commercialize innovative, socially and economically acceptable value-added foods, food additives and ingredients, nutraceuticals and other bioproducts from cool climate fruits.

加拿大拥有可持续的农业生物资源供应，其中不仅包括各种各样的农业商品，还包括农业生产和加工过程中产生的未充分利用的生物废物。世界卫生组织强调了不断变化的世界疾病概况。在北美，与氧化应激相关的慢性疾病流行病正面临重大挑战，这些疾病与饮食和环境直接或间接相关。因此，通过饮食调整进行化学预防，即增加水果和蔬菜的消费以及使用来自水果和蔬菜的新型食品成分，对于帮助管理当前和新出现的卫生保健挑战将非常重要。具有抗氧化和细胞信号调节特性的天然植物化合物，如多酚类、三萜类和类胡萝卜素，现在被科学界广泛认为是水果中的主要成分，它们提供了超出基本营养功能的特定健康益处。 拟议的研究将调查选定的水果化合物的功能，这些化合物可以有效地从加拿大未充分利用的水果中提取。拟议的研究将填补知识空白，了解凉爽气候水果，水果加工副产品和果园废物中存在的独特生物活性物质的生物功能和工业用途;选定的生物活性化合物及其衍生物的作用方式;以及食品加工的影响。ω-3多不饱和脂肪酸（PUFA）的食物模型系统将用于评估水果生物活性物质作为PUFA脂质的天然稳定剂。水果生物活性物质及其新衍生物的生物利用度和生物功能性将使用选定的动物研究模型系统进行研究，目的是开发针对选定的氧化应激治疗慢性疾病的功能性食品成分和营养品。研究的长期范围是开发和商业化创新的，社会和经济上可接受的增值食品，食品添加剂和配料，营养保健品和其他生物产品从凉爽的气候水果。