Synthetic transporters - Probes for the chemical space of the cellular membrane

该研究计划旨在构建能够靶向并渗透特定细胞的合成分子转运蛋白。因此，它将为将药物和诊断剂特定输送到其作用部位提供创新的解决方案。 目前，我们无法将药物引导至其作用部位。这种限制导致使用大剂量、增加副作用和增加成本。此外，当目标位于细胞内时，许多药物难以达到其目标。 拟议的计划将首先提供能够识别细胞表面糖胺聚糖形式的细胞指纹的新分子转运蛋白。然后转运蛋白会将货物分子导入选定的细胞内。拟议的研究计划还将产生有关细胞表面化学空间的丰富知识，这对于细胞生物学和药物输送非常有价值。 它结合了有机化学和药物化学、细胞生物学和生物物理学，将有助于高素质人才的跨学科培训。

This research program aims at building synthetic molecular transporters able to target and penetrate specific cells. As such, it will provide innovative solutions for the specific delivery of drugs and diagnostic agents to their site of action. Currently, we are not able to direct drugs to their site of action. This limitation imposes the use of large doses, added side effects and increased costs. Additionally, many drugs have difficulty reaching their target when the latter is located intracellularly. The proposed program will first provide new molecular transporters able to recognize cellular fingerprints in the form of cell surface glycosaminoglycans. The transporters will then import a cargo molecule inside the selected cells. The proposed research program will also generate a wealth of knowledge on the chemical space of the cellular surface, which will be valuable for cellular biology and drug delivery. It combines organic & medicinal chemistry, cellular biology, and biophysics, and will contribute to the interdisciplinary training of highly qualified personnel.