Synthetic transporters - Probes for the chemical space of the cellular membrane

这项研究计划旨在构建能够靶向并穿透特定细胞的合成分子转运体。因此，它将为将药物和诊断试剂具体运送到其行动地点提供创新的解决方案。 目前，我们无法将药物定向到他们的作用地点。这一限制强制使用大剂量、增加副作用和增加成本。此外，当后者位于细胞内时，许多药物很难到达靶点。 拟议的计划将首先提供能够识别细胞表面糖胺聚糖形式的细胞指纹的新的分子转运体。然后，转运体将在选定的细胞内输入一种货物分子。拟议的研究计划还将产生关于细胞表面化学空间的丰富知识，这些知识将对细胞生物学和药物输送具有价值。 它结合了有机与药物化学、细胞生物学和生物物理学，将有助于高素质人才的跨学科培养。

This research program aims at building synthetic molecular transporters able to target and penetrate specific cells. As such, it will provide innovative solutions for the specific delivery of drugs and diagnostic agents to their site of action. Currently, we are not able to direct drugs to their site of action. This limitation imposes the use of large doses, added side effects and increased costs. Additionally, many drugs have difficulty reaching their target when the latter is located intracellularly. The proposed program will first provide new molecular transporters able to recognize cellular fingerprints in the form of cell surface glycosaminoglycans. The transporters will then import a cargo molecule inside the selected cells. The proposed research program will also generate a wealth of knowledge on the chemical space of the cellular surface, which will be valuable for cellular biology and drug delivery. It combines organic & medicinal chemistry, cellular biology, and biophysics, and will contribute to the interdisciplinary training of highly qualified personnel.