Permeability improvements with fatty acid derivatives

脂肪酸衍生物改善渗透性

• 批准号: 515020-2017
• 负责人: Marsault, Eric
• 金额: $ 1.82万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=639704
• 关键词: Permeability; improvements; fatty; acid; derivatives

Neptune Wellness Solutions has a long-standing expertise in extraction of lipid-ased natural products. As partof its portfolio, it has developed several lipid-based additives that can increase the oral bioavailability oflipid-soluble products. It now wishes to better quantify and characterize the impact of these additives usingcellular permeability assays. This will be accomplished in collaboration with the medicinal chemistry team ofPr Eric Marsault, using parallel artificial membrane permeability assays and cell-based assays.Thus the project involves development of the assays and quantification of the permeability of diverse classes ofmolecules, including natural products and vitamins.

海王星保健解决方案在提取基于脂质的天然产品方面拥有长期的专业知识。作为其产品组合的一部分，它已经开发了几种脂类添加剂，可以提高脂溶产品的口服生物利用度。它现在希望使用细胞渗透性分析来更好地量化和表征这些添加剂的影响。这将与Pr Eric Marsault的药物化学团队合作完成，使用并行的人工膜渗透性分析和基于细胞的分析。因此，该项目涉及到分析的开发和不同类别分子的渗透性的量化，包括天然产品和维生素。