The role of zinc as a novel synaptic messenger in the brain

锌作为大脑中新型突触信使的作用

• 批准号: 386678-2011
• 负责人: Okamoto, Kenichi
• 金额: $ 2.05万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573009
• 关键词: role; zinc; novel; synaptic; messenger

Zinc is known as an abundant nutritionally essential element and present in a variety of tissues, including liver, muscle and brain. In the brain, zinc is present at high concentrations and selectively accumulates in pre-synaptic vesicles of glutamatergic synapses. Its synaptic activity-dependent release suggests an important role in synaptic plasticity and various brain functions such as learning and memory. However, understanding the role of dynamic zinc from pre-synaptic vesicles has been hampered by the inability to visualize the process in individual synapses. Developing novel zinc probes and optical methods, we propose to study how dynamic zinc regulates synaptic plasticity and various brain functions. Our studies will provide a new view for the function of zinc, which is essential for the processes of synaptic plasticity underlying learning and memory. The project will facilitate the unique signaling studies of other metals and establish a new class of messenger for various biological systems.

锌被认为是一种丰富的营养必需元素，存在于各种组织中，包括肝脏，肌肉和大脑。在大脑中，锌以高浓度存在，并选择性地积累在突触前囊泡的突触能突触。它的突触活性依赖性释放表明在突触可塑性和各种脑功能如学习和记忆中的重要作用。然而，了解动态锌的作用，从突触前囊泡一直阻碍了无法可视化的过程中，在个别突触。 开发新的锌探针和光学方法，我们建议研究动态锌如何调节突触可塑性和各种脑功能。 我们的研究将为锌的功能提供一个新的视角，锌在学习和记忆的突触可塑性过程中是必不可少的。 该项目将促进其他金属的独特信号研究，并为各种生物系统建立一类新的信使。