A simultaneous PET/MR system for whole body imaging

用于全身成像的同步 PET/MR 系统

• 批准号: 402124-2012
• 负责人: Peng, Hao
• 金额: $ 1.68万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=573166
• 关键词: simultaneous; PET; MR; system; whole

We plan to develop a high performance whole body Positron Emission Tomography (PET) system that can be inserted into an Magnetic Resonance (MR) system for simultaneous PET/MR imaging without performance degradation for both systems. The PET system will be configured as a ring of approximately 52 cm inner diameter and 20 cm axial dimension that fits within a whole body 3T MR system of 60 cm diameter bore. The NSERC financial support will help us build the necessary infrastructures and a 1/3rd of the full system for proof-of-principle. There are significant technology differences between the proposed whole body PET/MR and previous designs. First, the PET detectors are based upon silicon photomultipliers (SiPMs) and exhibit superior performances. Second, an electro-optically coupling scheme using laser diodes is deployed to minimize potential interferences between two systems. If successful, this proposal will lead to a truly simultaneous PET/MR hybrid system for whole body imaging. In addition to the benefits of PET/CT, the multiplicity of MR's anatomical information and PET's functional/molecular information will enable new paradigms for diseases diagnosis, prognosis and treatment in cancer screening/staging, cardiac imaging, therapy monitoring, and characterization of Alzheimer's disease. The proposed system will help physicians to detect diseases in the early stage with increase specificity and manage treatment plans more effectively. We believe that a simultaneous PET/MR system could ultimately make great impacts for advancing healthcare technology and improving quality of life in Canada. Economic benefits from commercialization and technology licensing through collaboration with industry partners are also expected.

我们计划开发一种高性能的全身正电子发射断层扫描（PET）系统，该系统可插入磁共振（MR）系统中，用于同时进行PET/MR成像，而两种系统的性能均不会降低。PET系统将配置为内径约为52 cm、轴向尺寸为20 cm的环，可安装在孔径为60 cm的全身3 T MR系统内。NSERC的财政支持将帮助我们建立必要的基础设施和完整系统的三分之一用于原理证明。申报的全身PET/MR与之前的设计之间存在显著的技术差异。首先，PET探测器是基于硅光电倍增管（SiPM），并表现出上级性能。其次，部署了使用激光二极管的电光耦合方案，以最大限度地减少两个系统之间的潜在干扰。如果成功的话，这一提议将导致一个真正的同步PET/MR混合系统的全身成像。除了PET/CT的益处之外，MR的解剖学信息和PET的功能/分子信息的多样性将使得能够在癌症筛查/分期、心脏成像、治疗监测和阿尔茨海默病的表征中进行疾病诊断、预后和治疗的新范例。该系统将帮助医生在早期发现疾病，提高特异性，并更有效地管理治疗计划。我们相信，同步PET/MR系统最终将对推进医疗技术和提高加拿大的生活质量产生重大影响。通过与行业伙伴的合作，商业化和技术许可也有望带来经济效益。