Hyperpolarized Xenon MRI Biosensors Development Program

在这个项目中，Mitchell Albert博士和他的同事正在开发一种名为超极化(HP)129Xe生物传感器MRI的生物医学工具，该工具将能够在体内实现分子功能的磁共振成像信息，这是以前从未做过的事情。艾伯特博士和他的同事们将开发用于HP 129Xe生物传感器磁共振成像的先进生物传感器，方法是合成附着在氙原子上的分子，并将这些“氙笼”分子连接到与细胞受体结合的亲和蛋白上。这项研究的创新之处在于，将现有的用于研究肺部和大脑的技术HP GAS MRI应用于一个全新的方向-开发先进的分子成像技术。为了实现这一新生物工程工具的开发，阿尔伯特博士将整合几种高度创新和强大的研究工具，包括分子生物标记探针，以及可以与蛋白质受体结合的专门亲和肽。

In this program, Dr. Mitchell Albert and colleagues are developing a biomedical tool called hyperpolarized (HP) 129Xe biosensor MRI that will be able to achieve in vivo MR imaging information on molecular function, something that has never before been done. Dr. Albert and colleagues are going to develop advanced biosensors for HP 129Xe biosensor MRI by synthesizing molecules that attach to xenon atoms, and connect those "xenon-cage" molecules to affinity proteins that bind to cellular receptors. This research is innovative in taking an existing technology that is well established for the study of the lungs and brain, HP gas MRI, and applying it in an entirely new direction-to develop an advanced molecular imaging technology. To achieve this development of this new bioengineering tool, Dr. Albert will integrate several highly innovative and powerful research tools, including molecular biomarker probes, and specialized affinity peptides that can bind to protein receptors.