Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
基本信息
- 批准号:RGPIN-2017-05359
- 负责人:
- 金额:$ 4.53万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Hyperpolarized (HP) Xenon magnetic resonance (MR) imaging biosensors have the potential to revolutionize the detection and characterization of disease and may perhaps one day provide a lower cost complement to positron emission tomography (PET) as a preferred method of molecular imaging. MR imaging biosensors have high spatial resolution (similar to MRI) with high sensitivity (similar to PET) without any of the ionizing radiation associated with PET. Additionally, xenon imaging biosensors are of significantly lower cost than PET. This lower cost and lack of ionizing radiation make these imaging biosensors more conducive to more frequent imaging studies.Molecular imaging is inherently non-invasive and therefore may have considerably lower risk to a patient than current histological or pathological studies (surgical biopsies). Imaging biosensors are designed to have a high affinity to a particular pathological molecule or cell within the body. These pathological areas of interest can be detected by applying one of many imaging modalities. Furthermore, molecular imaging may even differentiate between different forms of a particular disease. For example, molecular imaging has the potential to differentiate between two similar cancerous tumours: one which warrants aggressive treatment and another subtype which is better treated in a more conservative way. HP Xe MR imaging biosensors use a cage molecule that encapsulates a xenon atom. The applicants recently obtained the first ever in vivo images of a xenon biosensor contrast agent, paving the way for the creation of xenon gas imaging biosensors. In this project, we propose to develop, characterize and test, first in vitro and then in vivo, Xe imaging biosensors that will extend HP imaging with sensitive biosensors. In this research program, by combining a xenon cage molecule with a variety of affinity tags, we will develop biosensors and perform the basic research and engineering that will make HP Xe imaging a practical and affordable alternative to conventional PET imaging techniques. We intend to use our resources and expertise in HP gas MRI to address engineering challenges in fundamental chemistry and MRI engineering that will make HP gas imaging possible in vivo on the molecular level. This technique would have PET-like sensitivity with MRI-like resolution, without the use of ionizing radiation, all at a lower cost than existing PET studies. The fulfillment of our program goals have the potential to eventually render invasive biopsies a thing of the past.
超极化(HP)氙磁共振(MR)成像生物传感器有可能彻底改变疾病的检测和表征,也许有一天会提供一个较低的成本补充正电子发射断层扫描(PET)作为分子成像的首选方法。MR成像生物传感器具有高空间分辨率(类似于MRI)和高灵敏度(类似于PET),而没有任何与PET相关的电离辐射。此外,氙成像生物传感器的成本明显低于PET。这种低成本和电离辐射的缺乏使这些成像生物传感器更有利于更频繁的成像研究。分子成像本质上是非侵入性的,因此可能比目前的组织学或病理学研究(手术活检)对患者的风险低得多。成像生物传感器被设计为对体内特定病理分子或细胞具有高亲和力。这些感兴趣的病理区域可以通过应用许多成像模态中的一种来检测。此外,分子成像甚至可以区分特定疾病的不同形式。例如,分子成像有可能区分两种相似的癌性肿瘤:一种需要积极治疗,另一种亚型则需要更好的保守治疗。惠普核磁共振成像生物传感器使用笼状分子封装氙原子。申请人最近获得了氙生物传感器造影剂的首次体内图像,为氙气成像生物传感器的创建铺平了道路。在这个项目中,我们建议开发,表征和测试,首先在体外,然后在体内,HP成像生物传感器,将扩展HP成像与敏感的生物传感器。在这项研究计划中,通过将氙笼分子与各种亲和标签相结合,我们将开发生物传感器,并进行基础研究和工程设计,使HP PET成像成为传统PET成像技术的实用且负担得起的替代品。我们打算利用我们在HP气体MRI方面的资源和专业知识来解决基础化学和MRI工程方面的工程挑战,这将使HP气体成像在分子水平上在体内成为可能。这种技术将具有PET般的灵敏度和MRI般的分辨率,而不使用电离辐射,所有这些都比现有的PET研究成本更低。我们计划目标的实现有可能最终使侵入性活检成为过去。
项目成果
期刊论文数量(0)
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Albert, Mitchell其他文献
Investigation of hyperpolarized 3He magnetic resonance imaging utility in examining human airway diameter behavior in asthma through comparison with high-resolution computed tomography
- DOI:
10.1016/j.acra.2008.02.003 - 发表时间:
2008-06-01 - 期刊:
- 影响因子:4.8
- 作者:
Tzeng, Yang-Sheng;Hoffman, Eric;Albert, Mitchell - 通讯作者:
Albert, Mitchell
Adsorption of Maleic Acid Monomer on the Surface of Hydroxyapatite and TiO2: A Pathway toward Biomaterial Composites
- DOI:
10.1021/acsami.8b05128 - 发表时间:
2018-07-25 - 期刊:
- 影响因子:9.5
- 作者:
Albert, Mitchell;Clifford, Amanda;Rubel, Oleg - 通讯作者:
Rubel, Oleg
Explaining clustered ventilation defects via a minimal number of airway closure locations.
- DOI:
10.1007/s10439-008-9603-z - 发表时间:
2009-02 - 期刊:
- 影响因子:3.8
- 作者:
Mullally, William;Betke, Margrit;Albert, Mitchell;Lutchen, Kenneth - 通讯作者:
Lutchen, Kenneth
Measurement of the internal diameter of plastic tubes from projection MR images using a model-based least-squares fit approach
- DOI:
10.1118/1.2194427 - 发表时间:
2006-06-01 - 期刊:
- 影响因子:3.8
- 作者:
Tzeng, Yang-Sheng;Mansour, Joey;Albert, Mitchell - 通讯作者:
Albert, Mitchell
MRI of stroke using hyperpolarized 129Xe
- DOI:
10.1002/nbm.1568 - 发表时间:
2011-02-01 - 期刊:
- 影响因子:2.9
- 作者:
Zhou, Xin;Sun, Yanping;Albert, Mitchell - 通讯作者:
Albert, Mitchell
Albert, Mitchell的其他文献
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{{ truncateString('Albert, Mitchell', 18)}}的其他基金
Investigation of novel photoinduced magnetoelectric effect in magnetic material
磁性材料中新型光感磁电效应的研究
- 批准号:
RTI-2023-00177 - 财政年份:2022
- 资助金额:
$ 4.53万 - 项目类别:
Research Tools and Instruments
Wearable Electrochemical Saliva Sensor for Real-time Monitoring of Nucleic Acids and Proteins
用于实时监测核酸和蛋白质的可穿戴电化学唾液传感器
- 批准号:
566017-2021 - 财政年份:2021
- 资助金额:
$ 4.53万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
RGPIN-2017-05359 - 财政年份:2021
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
RGPIN-2017-05359 - 财政年份:2020
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
RGPIN-2017-05359 - 财政年份:2019
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
RGPIN-2017-05359 - 财政年份:2018
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
RGPIN-2017-05359 - 财政年份:2017
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
418209-2012 - 财政年份:2016
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
418209-2012 - 财政年份:2015
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
Hyperpolarized Xenon MRI Biosensors Development Program
超极化氙 MRI 生物传感器开发计划
- 批准号:
418209-2012 - 财政年份:2014
- 资助金额:
$ 4.53万 - 项目类别:
Discovery Grants Program - Individual
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XENON100暗物质实验的数据分析
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