Hyperpolarized Xenon MRI Biosensors Development Program

超极化氙 MRI 生物传感器开发计划

• 批准号: 418209-2012
• 负责人: Albert, Mitchell
• 金额: $ 2.99万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596256
• 关键词: Hyperpolarized; Xenon; MRI; Biosensors; Development

In this program, Dr. Mitchell Albert and colleagues are developing a biomedical tool called hyperpolarized (HP) 129Xe biosensor MRI that will be able to achieve in vivo MR imaging information on molecular function, something that has never before been done. Dr. Albert and colleagues are going to develop advanced biosensors for HP 129Xe biosensor MRI by synthesizing molecules that attach to xenon atoms, and connect those "xenon-cage" molecules to affinity proteins that bind to cellular receptors. This research is innovative in taking an existing technology that is well established for the study of the lungs and brain, HP gas MRI, and applying it in an entirely new direction-to develop an advanced molecular imaging technology. To achieve this development of this new bioengineering tool, Dr. Albert will integrate several highly innovative and powerful research tools, including molecular biomarker probes, and specialized affinity peptides that can bind to protein receptors.

在该项目中，Mitchell Albert博士及其同事正在开发一种名为超极化（HP）129纳米生物传感器MRI的生物医学工具，该工具将能够实现分子功能的体内MR成像信息，这是以前从未做过的。Albert博士及其同事将通过合成附着在氙原子上的分子，并将这些“氙笼”分子连接到与细胞受体结合的亲和蛋白质上，来开发用于HP 129生物传感器MRI的先进生物传感器。这项研究是创新性的，采用了现有的技术，这是很好地建立了肺部和大脑的研究，HP气体MRI，并将其应用于一个全新的方向，以开发一种先进的分子成像技术。为了实现这种新的生物工程工具的开发，Albert博士将整合几种高度创新和强大的研究工具，包括分子生物标志物探针和可以与蛋白质受体结合的专用亲和肽。