Hyperpolarized Xenon MRI Biosensors Development Program

超极化氙 MRI 生物传感器开发计划

• 批准号: RGPIN-2017-05359
• 负责人: Albert, Mitchell
• 金额: $ 3.28万
• 依托单位: Lakehead University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632243
• 关键词: Hyperpolarized; Xenon; MRI; Biosensors; Development

Hyperpolarized (HP) Xenon magnetic resonance (MR) imaging biosensors have the potential to revolutionize the detection and characterization of disease and may perhaps one day provide a lower cost complement to positron emission tomography (PET) as a preferred method of molecular imaging. MR imaging biosensors have high spatial resolution (similar to MRI) with high sensitivity (similar to PET) without any of the ionizing radiation associated with PET. Additionally, xenon imaging biosensors are of significantly lower cost than PET. This lower cost and lack of ionizing radiation make these imaging biosensors more conducive to more frequent imaging studies.

超极化(HP)氙气磁共振(MR)成像生物传感器有可能给疾病的检测和表征带来革命性的变化，也许有一天会成为正电子发射断层成像(PET)的低成本补充，成为分子成像的首选方法。磁共振成像生物传感器具有高空间分辨率(类似于核磁共振)和高灵敏度(类似于正电子发射计算机断层扫描)，没有任何与正电子发射计算机断层成像相关的电离辐射。此外，氙气成像生物传感器的成本比PET低得多。这种较低的成本和缺乏电离辐射使这些成像生物传感器更有利于更频繁的成像研究。