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Netherton Syndrome: From mechanism to therapies.

Netherton Syndrome: From mechanism to therapies.
内瑟顿综合症:从机制到治疗。
批准号:
331997
负责人:
Diamandis Eleftherios P
金额:
$5.15万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-06-01 至 2018-06-01

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中文摘要
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英文摘要
Netherton Syndrome (NS) is a life-threatening skin disease caused by mutations in the SPINK5 gene. These mutations inactivate an endogenous serine protease inhibitor, called LEKTI. In human skin LEKTI inhibits the activity of skin kallikreins (KLKs). K
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KaliDerm Therapeutics: A research/commercialization plan to validate, better define and add value to our proprietary dual KLK5/7 inhibitor as a novel topical therapeutic for Netherton Syndrome.
  • 批准号:
    462430
  • 项目类别:
    Operating Grants
  • 资助金额:
    $24.52万
  • 财政年份:
    2022
  • 负责人:
    Diamandis Eleftherios P
  • 依托单位:
Integrative PersonalizedRiskand Therapy Stratification of Localized Prostate Cancer
  • 批准号:
    388062
  • 项目类别:
    Operating Grants
  • 资助金额:
    $32.78万
  • 财政年份:
    2018
  • 负责人:
    Diamandis Eleftherios P
  • 依托单位:
Validation of two novel pancreatic cancer biomarkers: CUZD1 and LAMC2
  • 批准号:
    279678
  • 项目类别:
    Operating Grants
  • 资助金额:
    $37.86万
  • 财政年份:
    2013
  • 负责人:
    Diamandis Eleftherios P
  • 依托单位:
Integrated Approach to Discover Prostate Cancer Biomarkers in Seminal Plasma
  • 批准号:
    265566
  • 项目类别:
    Operating Grants
  • 资助金额:
    $30.4万
  • 财政年份:
    2012
  • 负责人:
    Diamandis Eleftherios P
  • 依托单位:
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