The need for neuromonitoring during the golden hour to prevent preterm brain injury
The need for neuromonitoring during the golden hour to prevent preterm brain injury
批准号:
478470-2015
负责人:
StLawrence, Keith
金额:
$4.91万
依托单位国家:
加拿大
项目类别:
Collaborative Health Research Projects
财政年份:
2015
资助国家:
加拿大
项目状态:
已结题
起止时间:
2015-01-01 至 2016-12-31
中文摘要
由于新生儿重症监护病房(NICU)的发展,早产的存活机会,定义为
在过去几十年中,怀孕37周前分娩的妇女人数稳步增加。不幸的是早产儿
特别是非常年幼(< 28周)和非常小(< 1000 g)的婴儿,非常容易受到脑损伤。这被认为
这是由于肺和心脏功能不佳以及大脑中的血管无法自我调节血液
流其结果可能是危险的低血流到大脑的时期,这可能导致永久性损伤。之一
最关键的时期是生命的最初几个小时,这段时间被称为黄金时间。本研究的目的是
开发一种易于使用的基于光的系统,用于在黄金时段监测脑血流。基于光
技术对于这种脆弱的患者群体是理想的,因为它们是非侵入性的,
头皮上的光源和探测器很少,非常安全。我们希望这项技术作为
该项目将及时检测脑血流异常,这将使NICU团队能够采取纠正措施,
恢复正常流量的措施。反过来,这将避免与终身医疗问题相关的脑损伤类型,
例如大脑性麻痹和学习障碍,不幸的是,这在早产儿中非常常见
英文摘要
Thanks to the development of the neonatal intensive care unit (NICU), the chances of surviving preterm birth, defined as a
birth before 37 weeks of pregnancy, has increased steadily over the past few decades. Unfortunately preterm infants,
particularly the very young (< 28 weeks) and very small (< 1000 g), are extremely vulnerable to brain injury. This is believed
to be due to the combination of poor lung and heart function and an inability of the vessels in the brain to self-regulate blood
flow. The result can be periods of dangerously low blood flow to the brain, which can lead to permanent damage. One of the
most critical times is the first few hours of life a period referred to as the golden hour. The objective of this study is to
develop an easy-to-use, light-based system for monitoring brain blood flow during the golden hour period. Light-based
technologies are ideal for this fragile patient population because they are non-invasive only requiring the placement of a
few light sources and detectors on the scalp and extremely safe. It is our hope that the technology developed as part of
this project will provide timely detection of brain flow abnormalities, which will enable the NICU team to take corrective
measures to restore normal flow. In turn, this will avoid the types of brain injury associated with life-long medical problems,
such as cerebral palsy and learning disabilities, that are unfortunately all too common amongst preterm babies
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Studying Dynamic Blood Flow/Metabolism Regulation in the Brain
-
批准号:RGPIN-2018-04492
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2022
-
负责人:StLawrence, Keith
-
依托单位:
Studying Dynamic Blood Flow/Metabolism Regulation in the Brain
-
批准号:RGPIN-2018-04492
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2021
-
负责人:StLawrence, Keith
-
依托单位:
Studying Dynamic Blood Flow/Metabolism Regulation in the Brain
-
批准号:RGPIN-2018-04492
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2020
-
负责人:StLawrence, Keith
-
依托单位:
Studying Dynamic Blood Flow/Metabolism Regulation in the Brain
-
批准号:RGPIN-2018-04492
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2019
-
负责人:StLawrence, Keith
-
依托单位:
Studying Dynamic Blood Flow/Metabolism Regulation in the Brain
-
批准号:RGPIN-2018-04492
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$3.64万
-
财政年份:2018
-
负责人:StLawrence, Keith
-
依托单位:
Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.
-
批准号:312450-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.99万
-
财政年份:2017
-
负责人:StLawrence, Keith
-
依托单位:
Combining optical neuromonitoring with a respiratory gas system to assess neurovascular function
-
批准号:RTI-2017-00661
-
项目类别:Research Tools and Instruments
-
资助金额:$10.01万
-
财政年份:2016
-
负责人:StLawrence, Keith
-
依托单位:
Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.
-
批准号:312450-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.99万
-
财政年份:2015
-
负责人:StLawrence, Keith
-
依托单位:
Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.
-
批准号:312450-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.99万
-
财政年份:2014
-
负责人:StLawrence, Keith
-
依托单位:
Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.
-
批准号:312450-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.99万
-
财政年份:2013
-
负责人:StLawrence, Keith
-
依托单位:
Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.
-
批准号:312450-2012
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$2.99万
-
财政年份:2012
-
负责人:StLawrence, Keith
-
依托单位:
Measuring cerebral oxidative metabolism by combining optical and magnetic resonance imaging methods
-
批准号:312450-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.09万
-
财政年份:2011
-
负责人:StLawrence, Keith
-
依托单位:
Measuring cerebral oxidative metabolism by combining optical and magnetic resonance imaging methods
-
批准号:312450-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.09万
-
财政年份:2010
-
负责人:StLawrence, Keith
-
依托单位:
Measuring cerebral oxidative metabolism by combining optical and magnetic resonance imaging methods
-
批准号:312450-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.09万
-
财政年份:2009
-
负责人:StLawrence, Keith
-
依托单位:
Measuring cerebral oxidative metabolism by combining optical and magnetic resonance imaging methods
-
批准号:312450-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.09万
-
财政年份:2008
-
负责人:StLawrence, Keith
-
依托单位:
Measuring cerebral oxidative metabolism by combining optical and magnetic resonance imaging methods
-
批准号:312450-2007
-
项目类别:Discovery Grants Program - Individual
-
资助金额:$1.09万
-
财政年份:2007
-
负责人:StLawrence, Keith
-
依托单位:
海外基金