Development of an Optical System to Study the Dynamic Regulation of Blood Flow and Oxygenation in the Cerebral Microvasculature.

开发光学系统来研究脑微血管系统中血流和氧合的动态调节。

• 批准号: 312450-2012
• 负责人: StLawrence, Keith
• 金额: $ 2.99万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632926
• 关键词: Development; Optical; System; Study; Dynamic

Due to the brain's high energy demands, its blood flow is highly regulated in order to maintain a continuous supply of oxygen and nutrients. Because of the tight coupling between brain blood flow and energy metabolism, cerebrovascular dysfunction is believed to not only play a critical role in vascular diseases such as stroke, but in neurodegenerative diseases as well. This proposal will focus on the development of a non-invasive, safe optical system capable of assessing the dynamic control of brain blood flow and oxygenation. Initial experiments are aimed at confirming the accuracy of the developed technology and demonstrating its capability using healthy volunteers. Ultimately this technology could be used to better understand how diseases, such as Alzheimer's, alter the critical the link between brain blood flow and proper brain function.

由于大脑对能量的需求很高，它的血液流动受到高度调节，以维持持续的氧气和营养供应。由于脑血流和能量代谢之间的紧密耦合，脑血管功能障碍被认为不仅在中风等血管疾病中起关键作用，而且在神经退行性疾病中也起着关键作用。这项提议将集中于开发一种非侵入性的、安全的光学系统，能够评估脑血流和氧合的动态控制。初步实验的目的是确认开发的技术的准确性，并在健康志愿者身上展示其能力。最终，这项技术可以被用来更好地理解阿尔茨海默氏症等疾病如何改变大脑血流和正常大脑功能之间的关键联系。