Biomaterial substrates for xeno- and feeder layer-free culture of human pluripotent stem cells

用于人类多能干细胞的无异种和饲养层培养的生物材料基质

基本信息

  • 批准号:
    478473-2015
  • 负责人:
  • 金额:
    $ 8.55万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Collaborative Health Research Projects
  • 财政年份:
    2015
  • 资助国家:
    加拿大
  • 起止时间:
    2015-01-01 至 2016-12-31
  • 项目状态:
    已结题

项目摘要

Pluripotent stem cells are a promising tool for future applications in human therapeutics. Their ability to contribute to potentially all tissues and organs in the human body makes them highly valuable for tissue engineering, organ replacement, and pharmaceutical research. The culture conditions in which pluripotent stem cells are derived and maintained still contain animal or human blood products that are of potential risk for recipients, as they may contain viruses, bacteria or other harmful bioactive molecules. Our research project will develop new synthetic protein-coated polymers as attachment and growth matrices for human pluripotent stem cell cultures. These chemically defined substrates will eliminate the risk of pathogen transmission in subsequent human pluripotent stem cell applications, providing an important step towards safe, clinical grade culture products for human stem cells. Moreover, our synthetic polymers will be more cost-effective, standardized and reproducible than existing methods. Since it is now possible to generate patient-specific stem cell lines, our technologies will assist future personalized therapies for patients suffering from chronic conditions like arthritis, diabetes, or heart disease. Four out of five Canadians at a risk to develop degenerative chronic diseases, and therefore our technologies have strong potential to indirectly improve the health of Canadians. Canada is among the world leaders in human stem cell research. Our strongly translational research project will be of great benefit for the Canadian commercial stem cell sector and will train highly qualified personnel with interdisciplinary expertise and professional skills immediately relevant to Canadas growing biotechnology and regenerative medicine sectors.
多能干细胞是一种很有前途的工具,用于未来的人类治疗。他们对…的贡献能力

项目成果

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Simmons, Craig其他文献

Simmons, Craig的其他文献

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{{ truncateString('Simmons, Craig', 18)}}的其他基金

Integrated biosensors for organ-on-a-chip and physiological monitoring platforms
用于芯片器官和生理监测平台的集成生物传感器
  • 批准号:
    RGPIN-2022-04375
  • 财政年份:
    2022
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Discovery Grants Program - Individual
Melt electrowrite system for biofabrication of complex engineered tissues
用于复杂工程组织生物制造的熔体电写系统
  • 批准号:
    RTI-2023-00475
  • 财政年份:
    2022
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Research Tools and Instruments
Biosensing for organ-on-a-chip platforms
器官芯片平台的生物传感
  • 批准号:
    RGPIN-2016-06026
  • 财政年份:
    2021
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Discovery Grants Program - Individual
Biosensing for organ-on-a-chip platforms
器官芯片平台的生物传感
  • 批准号:
    RGPIN-2016-06026
  • 财政年份:
    2020
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Discovery Grants Program - Individual
A microfluidic blood-brain barrier model with on-chip cell barrier biosensing
具有片上细胞屏障生物传感的微流体血脑屏障模型
  • 批准号:
    531083-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Collaborative Research and Development Grants
Biosensing for organ-on-a-chip platforms
器官芯片平台的生物传感
  • 批准号:
    RGPIN-2016-06026
  • 财政年份:
    2019
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Discovery Grants Program - Individual
Development of a physiological cardiac microtissue platform for drug development
开发用于药物开发的生理心脏微组织平台
  • 批准号:
    508366-2017
  • 财政年份:
    2018
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Collaborative Health Research Projects
Engineering Pulmonary Valve Tissue for Pediatric Patients with Tetralogy of Fallot
法洛四联症儿科患者的肺瓣组织工程
  • 批准号:
    508364-2017
  • 财政年份:
    2018
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Collaborative Health Research Projects
A microfluidic blood-brain barrier model with on-chip cell barrier biosensing**
具有片上细胞屏障生物传感的微流体血脑屏障模型**
  • 批准号:
    531083-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Collaborative Research and Development Grants
Biosensing for organ-on-a-chip platforms
器官芯片平台的生物传感
  • 批准号:
    RGPIN-2016-06026
  • 财政年份:
    2018
  • 资助金额:
    $ 8.55万
  • 项目类别:
    Discovery Grants Program - Individual

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事业:采用晶格工程基板实现高效紫外线发射器
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DYRK 蛋白激酶的新底物和功能
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  • 批准号:
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用于高效生产有机化学品的循环和生物底物的电化学氧化 (ELOXYCHEM)
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循环和生物底物的电化学氧化,用于高效生产有机化学品
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职业:解卷积有机底物作为有机物变化与全球生物地球化学硫、碳和氧循环之间的关键联系
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