Application of functional near-infrared imaging as a biomarker of injury and recovery in mild traumatic brain injury and concussion

功能性近红外成像作为轻度创伤性脑损伤和脑震荡损伤和恢复的生物标志物的应用

• 批准号: 478476-2015
• 负责人: Dunn, Jeff
• 金额: $ 6.06万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579541
• 关键词: Application; functional; near; infrared; imaging

Concussion and brain injury are now being recognized as a major health issue for Canadians. This problem may be especially severe in pediatric populations where brain injury could have life long implications and since children are more likely than adults to have persistent symptoms. In many sports, returning to activity before one is ready seems to increase the risk of further injury. We need to have a bette understanding of the actual injury and we need better tools to quantify the injury. MRI is a possibility but it will be limited by access and cost. We have discovered that regional brain communication may be impaired in brain injury and that this can be detected with a portable brain imaging system based on light. This method, functional near-infrared spectroscopy (fNIRS) can be used like MRI to detect brain activation but it can be done in a doctors office or playing field. We will expand our knowledge of brain communication as a marker of brain injury by measuring in different brain regions as well as in both pediatric and adult populations. We will improve the technology to make it more suitable for use by physicians and we will work with a Canadian company to determine if it is medically relevant and commercially viable to produce a fNIRS based concussion meter.

脑震荡和脑损伤现在被认为是加拿大人的一个主要健康问题。这个问题可能是 特别是在儿童人群中，脑损伤可能会终身影响， 比成年人更有可能出现持续的症状。在许多运动中，在准备好之前返回活动似乎会增加 进一步伤害的风险。我们需要更好地了解实际的伤害，我们需要更好的工具来量化 损伤MRI是一种可能性，但它将受到访问和成本的限制。我们发现大脑的区域交流 可能在脑损伤中受损，并且这可以用基于光的便携式脑成像系统来检测。这 方法，功能近红外光谱（fNIRS）可以像MRI一样用于检测大脑激活，但它可以在一个 医生办公室或运动场。我们将通过以下方式扩大我们对大脑通讯作为脑损伤标志的知识： 在不同的大脑区域以及儿童和成人人群中进行测量。我们将改进技术， 使其更适合医生使用，我们将与加拿大公司合作，以确定它是否与医学相关 并且在商业上可行以生产基于fNIRS的震荡计。