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Wirelessly-controlled addressable magnetic microfluidic valves

无线控制的可寻址磁性微流阀

基本信息

批准号：
478952-2015
负责人：
Diller, Eric
金额：
$ 1.82万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Engage Grants Program
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=579864
关键词：
Wirelessly controlled addressable magnetic microfluidic

项目摘要

Microfluidic technology uses miniature fluidic channels built on a compact chip for fluidic and biomedical diagnostic and research applications. Bio-Rad Laboratories Canada is a global biotechnology company which designs and manufactures equipment and tools for studying biological specimens, with increasing interest on microfluidic systems. Microfluidic systems can be fabricated with many channels and functional elements on one chip for parallel operation. Such capability offers increased functionality and ease of use in a single operating device. One significant challenge in the control of such parallel microfluidic systems is in the independent control of fluid and cell flow through the device channels. Previous methods for addressable channel flow involve valves with multi-layer construction actuated by compressed air, magnetic fields or other means. While such schemes have demonstrated their effectiveness for sophisticated arrays of parallel channels, all existing designs require channels with complex multi-layer fabrication and a large number of physical connections from the chip to pneumatic and fluidic control inputs. The proposed new collaboration with Bio-Rad will solve this problem through the use addressable magnetic valve elements which require no physical connection. This will result in a simple microfluidic chip which retains the high level of functionality shown in pneumatic parallel-channel control systems. Using magnetic addressing methods developed for microrobotic control, magnetic addressing of valves will be accomplished with simple magnetic coils nearby but not in contact with the microfluidic chip. This will result in a simple microfluidic chip design with potential for scaled production.

微流控技术使用构建在紧凑芯片上的微型流体通道，用于流体和生物医学诊断和研究应用。加拿大Bio-Rad实验室是一家全球生物技术公司，设计和制造用于研究生物标本的设备和工具，人们对微流体系统的兴趣越来越大。微流体系统可以在一个芯片上制造有许多通道和功能元件以用于并行操作。这种能力在单个操作设备中提供了增加的功能和易用性。控制这种并行微流体系统的一个重大挑战是独立控制通过装置通道的流体和细胞流动。用于可寻址通道流动的先前方法涉及具有由压缩空气、磁场或其它致动的多层构造的阀。手段虽然这种方案已经证明了它们对于复杂的平行通道阵列的有效性，但是所有现有的设计都需要具有复杂的多层制造和从芯片到气动和流体控制输入的大量物理连接的通道。拟议中的与Bio-Rad的新合作将通过使用不需要物理连接的可寻址磁阀元件来解决这个问题。这将导致简单的微流体芯片，其保留了气动平行通道控制系统中所示的高水平功能。使用为微机器人控制开发的磁寻址方法，阀门的磁寻址将通过附近但不与微流体芯片接触的简单磁线圈来完成。这将导致具有规模化生产潜力的简单微流体芯片设计。