Technology for clean and scalable synthesis of metal-organic frameworks

拟议的申请旨在将最近开发的用于克级微孔金属有机框架（mof）制造的新清洁技术（US 62/119,436）扩展到用于制造多种mof的100 - 10千克/天的批量工艺。这种经过验证的清洁制造工艺将为建立和合并一家名为Q-MOF的初创公司奠定基础，该公司将成为第一家商业化提供复杂且廉价的mof用于学术研究，以及在气体净化、氢燃料电池、甲烷和乙炔储存、二氧化碳封存和催化方面的商业机会。虽然少数制造商最近开始商业化提供数量非常有限的mof，但这些材料的成本过高（每公斤1.2万美元）。此外，现有的生产这些材料的工艺具有高环境影响和安全风险的特点，并且涉及腐蚀性起始材料和苛刻的反应条件。我们最近的专利技术允许从知名和安全的试剂中廉价，简单和环保地合成各种mof。拟议的研究将使我们能够扩大清洁和廉价的MOF制造技术，并扩大可获得的MOF产品组合，将使我们能够建立一家MOF制造公司，通过提供大量（10-100kg）的MOF产品，以比目前提供的价格低50%或更低的价格，满足新兴研究和工业应用市场的需求。我们最初的预期市场是吸附剂，重点是燃料电池技术，但我们也旨在为研究用户提供具有各种应用的产品。

The proposed application aims to scale up a recently-developed new and clean technology (US 62/119,436) for gram-scale manufacturing of microporous metal-organic frameworks (MOFs) into a >10 kilogram/day batch process for manufacturing multiple types of MOFs. This proven clean manufacturing process will provide a foundation to establish and incorporate a start-up company, called Q-MOF, which will be the first to commercially provide sophisticated and inexpensive MOFs for applications in academic research, as well as commercial opportunities in gas purification, hydrogen fuel cells, storage of methane and acetylene, carbon dioxide sequestration, and catalysis. Although a small number of manufacturers have recently begun commercially offering a very limited number of MOFs, these materials are available only at exorbitant cost (>$12,000 per kg). As well, the existing processes through which these materials are made are characterized by high environmental impact and safety risks, and involve corrosive starting materials and harsh reaction conditions. Our recently patented technology allows for the inexpensive, simple and environmentally-friendly synthesis of a wide diversity of MOFs from well-known and safe reagents. The proposed research, which will allow us to scale-up our clean and inexpensive MOF manufacturing technology and expand the portfolio of accessible MOF products, will enable us to establish a MOF manufacturing company that will meet the needs of the emerging research and industrial applications markets by providing large amounts (10-100kg) of MOF products for a price that is 50% or less than what is currently offered.Our initial expected market is adsorbents, with a focus on fuel cell technology, but we also aim to provide products to research users with a variety of applications.