Reclaiming Waste Phosphorus from Industrial Drug Manufacturing Systems

Emerent Biosolutions是一家生物制药公司，在马尼托巴省温尼伯经营着一家主要工厂， 以及加拿大和美国的其他国家。温尼伯工厂生产超级免疫和 他们在加拿大销售并出口的特定生物制药。在正常的生产过程中， 磷(P)在短时间内排入城市下水道系统，但浓度较高。作为计划的一部分 减少进入下水道系统的磷的新努力，该公司被要求减少总磷排放 温尼伯市。去除多余磷的标准废水方法包括添加金属 用于将磷絮凝成金属/磷酸盐污泥的盐，该污泥被处置在垃圾填埋场。然而， 由于这种做法将一种废物流转化为另一种废物流，因此它不是一个可持续的解决方案，浪费了潜在的 有价值的营养物质和增加的总体运营成本，而不会增加公司的收益或更多 社会。目前，该设施释放的磷浓度高，不受有机污染 固体或金属，为生产鸟粪石提供良好的潜在原料，一种缓释肥料，具有 利基农业和生态应用。理想情况下，该设施将调整并合并其他“内部”设施 生产鸟粪石所需的额外成分，即镁、铵和 PH调节所需的碱。Emerent面临的挑战是识别和适应这些废流 在他们的设施内，然后生产和销售这种新的鸟粪石产品。建议的研究项目 致力于处理和组合应急设施中现有的废物流，以进行沉淀和回收 工厂目前释放的99.4%的磷。这一目标将通过以下方式实现：a)对 当前的废流与磷酸盐废物的纯度和浓度相匹配，以及B)优化a 采用可变投料底物的沉淀反应器，去除大部分以鸟粪石形式存在的废磷。 这项提案的研究目标的成功将有利于温尼伯市和大湖 温尼伯盆地，因为它减少了湖泊中的磷负荷，并产生了一种有价值的肥料产品。

Emergent Biosolutions is a biopharmaceutical company that operates a major facility in Winnipeg, Manitoba, as well as others across Canada and the United States. The Winnipeg facility produces hyperimmunes and specific biopharmaceuticals which they market in Canada and export. During the normal production process, phosphorus (P) is discharged to the city sewer system in short durations, but at high concentrations. As part of a new effort to reduce phosphorus entering the sewer system, the company was asked to reduce total P release by the City of Winnipeg. Standard wastewater methods to remove excess phosphorus involve additions of metal salts to flocculate phosphorus into a metal/phosphate sludge, which is disposed at a landfill site. However, since this practice converts one waste stream into another, it is not a sustainable solution, wasting a potentially valuable nutrient and increasing overall operational costs without increasing benefit for the company or greater society. Currently, the phosphorus released by the facility is high in concentration, uncontaminated by organic solids or metals, providing a good potential feed stream for producing struvite, a slow-release fertilizer with niche agricultural and ecological applications. Ideally, the facility would adapt and combine other "in house" waste streams to supply the additional components to produce struvite, namely magnesium, ammonium and the alkali needed for pH adjustment. The challenge for Emergent is to identify and adapt these waste streams within their facility and then to produce and market this new struvite product. The proposed research project endeavours to process and combine existing waste streams in the Emergent facility to precipitate and reclaim 99.4% of the phosphorus currently released by the plant. This goal will be satisfied by: A) pre-treatment of current waste streams to match the purity and concentration of the phosphate waste, and B) optimization of a precipitation reactor accepting variable feed substrate to remove the majority of waste phosphorus as struvite. Success in the research goals of this proposal will be of benefit to the City of Winnipeg and the greater Lake Winnipeg Basin because it reduces phosphorus loading to the lake and produces a valuable fertilizer product.