Systemic Human Toxicity Assessment of Pesticide Mixtures

评估污染物的潜在毒性是一项持续的挑战，特别是在评估 环境样品（土壤、地下水）中的复杂混合物。省际合作社有限公司 （IPCO）目前正面临这一挑战，其农业化学品配方和包装设施位于 温尼伯。对该地点地下水和土壤的测试显示， 高于国家标准。这项资助将使用生物分析工具（使用哺乳动物的体外测定）， 细胞系），以评估从现场收集的土壤和地下水的潜在毒性，并提供快速的 对潜在的人类健康危害进行现实的评估。在该项目结束时，IPCO将拥有 关于在受污染土壤和地下水中发现的农药混合物对人体潜在毒性的数据 作为各研究中心毒性空间差异的初步地图。该项目将使我们能够开发和 应用体外生物测定工具评估对加拿大具有经济重要性的受污染场地。

Assessing the potential toxicity of contaminants represents an ongoing challenge, in particular when assessing complex mixtures from environmental samples (soil, groundwater). Interprovincial Cooperative Limited (IPCO) is currently facing this challenge with an agricultural chemicals formulation and packaging facility in Winnipeg. Testing of groundwater and soil at this site has revealed detected several pesticides at concentrations greater than national guideline levels. This grant will use bioanalytical tools (in vitro assays using mammalian cell lines) to assess the potential toxicity of soil and groundwater collected from the site and provide a rapid and realistic assessment of potential human health hazard. At the conclusion of this project, IPCO will have data on the potential human toxicity of pesticide mixtures found in contaminated soil and groundwater as well as preliminary map of spatial differences in the toxicity across site. This project will allow us to develop and apply in vitro bioassay tools to assess a contaminated site of economic importance to Canada.