Design and synthesis of spin-labelled compounds for NMR-protein-labelling experiments

用于 NMR 蛋白质标记实验的自旋标记化合物的设计和合成

• 批准号: 490658-2015
• 负责人: Snieckus, Victor
• 金额: $ 1.82万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=586564
• 关键词: Design; synthesis; spin; labelled; compounds

The aim of this collaboration is to prepare spin-labelled compounds (SLCs) for NMR-Protein-Labelling Experiments on the serine protease Granzyme B (GzmB). We will work to develop new chemistry to gain access to these compound and provide viDA new methods to synthesize new SLCs. This project will also provide a basis for further collaboration with viDA to develop SLCs for their potential use in design and synthesis of novel therapeutics against other target proteins in viDA's pipeline. Through this work we will also train highly qualified workers for the Canadian labour market.

这项合作的目的是为NMR-蛋白质标记制备自旋标记化合物（SLC） 丝氨酸蛋白酶粒酶B（Gzm B）的实验。我们将致力于开发新的化学物质， 并为合成新的SLCs提供了新的方法。该项目还将 为与维达进一步合作开发SLC提供基础，以便在设计和 维达正在开发针对其他靶蛋白的新型治疗药物。通过这项工作，我们还将 为加拿大劳动力市场培养高素质的工人。