Synthesis of deuterium labelled compounds for potential use in pain therapy

点击翻译按钮获取中文摘要

Before the synthesis of urea in 1828, organic molecules were available only through biological processes. Continuous advances in the chemical sciences has led to development of methods that can be used for the design and synthesis of complex molecules. Many of these synthetic molecules have found wide range of applications including as crop protection agents, cosmetics, food preservatives and medicines. Among several classes of synthetic molecules, deuterated medicinal compounds are of extraordinary interest due to their applications as modern pharmaceutical agents. However, their methods of preparation are challenging and require expensive starting materials. For this reason, there has been special interest in developing new methods for the synthesis of deuterated medicinal compounds for testing against new diseases or for many other biological studies. Through this proposal, we plan to develop efficient synthetic methodologies to prepare biologically important deuterated pharmaceutical compounds (e.g. Silodosin, Canagliflozen, Ledipasvir, Vilazodone) for their use in the pharmaceutical industry. Previous methods such as the directed ortho metalation (DoM) reaction, discovered and developed in our laboratories, are being used by the pharmaceutical industry (e.g. Monsanto, Pfizer, BMS, Merck) for the multikilogram commercial production of drugs, agrochemicals, and other commodity chemicals. This research proposal aims to help produce less expensive drugs and hence provide health and economic benefits to Canadians. Through this work we will also train highly qualified workers for the Canadian labour market.