New Synthetic Strategies & Methods for Bioactive Aromatics and Heteroaromatics

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Today, driving most advances in biology and material science is the science and art of making molecules – chemical synthesis. It allows for the practical supply of medicinals and materials that are difficult or impossible to acquire otherwise; it has profound consequences on human health (most therapeutic agents are synthesis-derived) and our standards of living (nanotubes, conducting polymers, smart phones, sensors). Fundamental discoveries in synthesis are at the heart of practical impact decades later, e.g. the 2010 Nobel and the 2014 Nobel (awarded for optical microscopy “allowing us to peer into the nanoworld” and track e.g. Alzheimer disease), is based on organic synthesis. The understanding of relationship of RNA and DNA is dependent on questions such as “why pentose and not hexose nucleic acids?” asked by organic chemists which will allow understanding of how life began (our prebiotic origins). Such basic questions must be answered before application in society, usually 20 years hence, can result.