New Synthetic Strategies & Methods for Bioactive Aromatics and Heteroaromatics

新的合成策略

• 批准号: RGPIN-2015-05698
• 负责人: Snieckus, Victor
• 金额: $ 5.39万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590584
• 关键词: New; Synthetic; Strategies; Methods; Bioactive

Today, driving most advances in biology and material science is the science and art of making molecules – chemical synthesis. It allows for the practical supply of medicinals and materials that are difficult or impossible to acquire otherwise; it has profound consequences on human health (most therapeutic agents are synthesis-derived) and our standards of living (nanotubes, conducting polymers, smart phones, sensors). Fundamental discoveries in synthesis are at the heart of practical impact decades later, e.g. the 2010 Nobel and the 2014 Nobel (awarded for optical microscopy “allowing us to peer into the nanoworld” and track e.g. Alzheimer disease), is based on organic synthesis. The understanding of relationship of RNA and DNA is dependent on questions such as “why pentose and not hexose nucleic acids?” asked by organic chemists which will allow understanding of how life began (our prebiotic origins). Such basic questions must be answered before application in society, usually 20 years hence, can result.

今天，推动生物学和材料科学取得最大进步的是制造分子的科学和艺术--化学合成。它允许以其他方式难以或不可能获得的药物和材料的实际供应；它对人类健康(大多数治疗剂是合成衍生的)和我们的生活标准(纳米管、导电聚合物、智能手机、传感器)具有深远的影响。合成方面的基本发现是几十年后实际影响的核心，例如2010年的诺贝尔奖和2014年的诺贝尔奖(授予光学显微镜奖，以使我们能够窥探纳米世界并追踪例如阿尔茨海默病)是基于有机合成的。对RNA和DNA之间关系的理解依赖于这样的问题：“为什么是戊糖而不是己糖？”由有机化学家提出，这将有助于理解生命是如何开始的(我们的生命前起源)。这些基本问题必须得到回答，然后才能在社会上应用，通常是20年后。