Hyperspectral Scanning Laser Ophthalmoscope for Alzheimer's Disease

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Alzheimer's Disease (AD) is commonly associated with neurodegeneration and an accumulation of senile plaques in the brain. Neurologists currently use radioactive labels to visualize the severity of the plaques in the brain, a process that is time consuming, costly, and exposes the patients to radiation. Recent research results suggest that the sample plaques are deposited in the neural tissues of the retina, located at the back of the eye. Dr. Sarunic and Canadian company Optina Diagnostics are each developing novel technology for visualization of the plaques in the retina minimally invasively in anticipation of lowering the costs of imaging and monitoring AD patients. The purpose of this research proposal is to investigate a novel optical imaging system using Optina's hyperspectral technology for detection of AD plaques in the eye. Dr. Sarunic's research group is experienced in the development of ophthalmic imaging systems, and interested in retinal diagnostics for AD. This Engage research project will facilitate a new collaboration, and the investigation of novel medical imaging instrumentation.