Two photon imaging and optoporation or retinal cells

两个光子成像和光孔或视网膜细胞

• 批准号: RTI-2018-00960
• 负责人: Sarunic, Marinko
• 金额: $ 10.93万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642301
• 关键词: Two; photon; imaging; optoporation; retinal

Pharmacological treatments are available for wet Age-related Macular Degeneration (AMD), a leading cause of blindness. In contrast, there is currently no effective treatment for many other irreversible vision robbing diseases, such as dry AMD and glaucoma. The delivery of therapeutic agents to the afflicted cells of the retina is hampered by their location at the back of the eye. In order to get treatments to the retina, the protective features of the eye must be overcome. Nanoparticles are versatile vehicles for delivery of therapeutics to the retina, but often have low uptake in the desired cell layers.

药物治疗可用于湿性黄斑变性（AMD），这是失明的主要原因。相比之下，目前对于许多其他不可逆的视力剥夺疾病，如干性AMD和青光眼，没有有效的治疗方法。将治疗剂递送至视网膜的患病细胞受到其在眼睛后部的位置的阻碍。为了治疗视网膜，必须克服眼睛的保护功能。纳米颗粒是用于将治疗剂递送至视网膜的通用载体，但在所需细胞层中通常具有低摄取。