Energy sensing in skeletal muscle: focus on mitochondrial metabolic adaptation

骨骼肌能量传感：关注线粒体代谢适应

• 批准号: RGPIN-2015-04286
• 负责人: Kane, Daniel
• 金额: $ 1.75万
• 依托单位: St. Francis Xavier University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589706
• 关键词: Energy; sensing; skeletal; muscle; focus

: Often referred to as the “powerhouses of the cell,” mitochondria have long been recognized as key producers of ATP, the cellular metabolic currency. In recent decades, however, mitochondria have increasingly been implicated in many additional cell processes, ranging from cellular calcium homeostasis to even cell death. In skeletal muscle, the energetic demands placed on the cell can fluctuate rapidly as an organism transitions between rest and exercise. Some of the purturbations in cellular redox state that occur in muscle with exercise are known to constitute a stimulus for acute alterations in mitochondrial function, as well as mitochondrial turnover and biogenesis.

：线粒体通常被称为“细胞的发动机”，长期以来一直被认为是细胞代谢货币ATP的关键生产者。然而，近几十年来，线粒体越来越多地参与了许多额外的细胞过程，从细胞钙稳态到甚至细胞死亡。在骨骼肌中，当有机体在休息和运动之间转换时，施加在细胞上的能量需求可以迅速波动。运动中肌肉细胞氧化还原状态的一些扰动被认为是线粒体功能以及线粒体周转和生物发生的急性改变的刺激因素。