Evolution of Potassium Channels and Nerve Networks in Cnidaria

刺胞动物钾通道和神经网络的进化

• 批准号: RGPIN-2015-04421
• 负责人: Gallin, Warren
• 金额: $ 1.75万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589792
• 关键词: Evolution; Potassium; Channels; Nerve; Networks

All animals have nervous systems – tissues formed of excitable cells that transmit and integrate information between different parts of the body. The structure and activity of nervous systems varies widely between organisms, from the relatively dispersed neural networks of the Cnidaria to the many anatomically different centralized nervous systems of the Bilateria. However, all cells of the nervous systems of all animals are electrically responsive. Ion channel proteins, both ligand-gated, which respond to neurotransmitters at the synapse and extra-synaptic modulatory signals, and voltage-gated, which respond to changes in membrane potential, modulate the membrane potential. This proposal describes a program aimed at identifying and characterizing the voltage-gated potassium channels in the cnidarian,

所有的动物都有神经系统——由可兴奋的细胞组成的组织，在身体的不同部位之间传递和整合信息。神经系统的结构和活动在不同生物之间差别很大，从刺胞动物相对分散的神经网络到两侧动物许多解剖学上不同的集中神经系统。然而，所有动物的神经系统的所有细胞都有电反应。离子通道蛋白对突触和突触外的神经递质调节信号作出反应的配体门控蛋白和对膜电位变化作出反应的电压门控蛋白调节膜电位。该提案描述了一个旨在识别和表征刺胞细胞中电压门控钾通道的程序。