Comparative analysis of voltage-gated potassium channels and inhibitors
Comparative analysis of voltage-gated potassium channels and inhibitors
批准号:
36402-2010
负责人:
Gallin, Warren
金额:
$1.97万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2011
资助国家:
加拿大
项目状态:
已结题
起止时间:
2011-01-01 至 2012-12-31
中文摘要
电压门控钾通道(VKC)在调节动物细胞膜电位方面发挥着重要作用。 凭借它们对膜电位变化的响应,它们可以打开和关闭,从而改变钾离子电导,从而改变钾离子电导,从而改变其对膜电位的贡献,如戈德曼方程所述。 由于存在大量不同基因和受调节的 mRNA 剪接,动物通常可以表达大量 VKC。 大量蛋白质序列变体具有总体相似的结构,但在影响通道电压敏感性、打开和关闭速率及其对一系列毒素的敏感性的重要细节上有所不同。
英文摘要
Voltage-gated potassium channels (VKCs) have an essential role in regulating the membrane potential in animal cells. By virtue of their response to changes in membrane potential they can open and close, altering the potassium ion conductance and thus its contribution to the membrane potential, as described by the Goldman equation. Animals typically can express a multitude of VKCs, by virtue of the presence of a large number of different genes and regulated mRNA splicing. The large number of protein sequence variants have structures that are similar in general, but that differ in significant details that affect the voltage sensitivity of the channel, the rate at which it opens and closes, and its susceptibility to a range of toxins.
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