Insecticide-induced hormesis in insects

杀虫剂引起的昆虫毒物兴奋作用

• 批准号: RGPIN-2015-04639
• 负责人: Cutler, Gerald
• 金额: $ 2.33万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589922
• 关键词: Insecticide; induced; hormesis; insects

Very low doses of insecticide can have stimulatory effects on insects. This biphasic toxicological phenomenon, whereby a chemical may be toxic at high doses but stimulatory at low doses is called ‘hormesis’. We previously showed that exposure of insects to mild doses of insecticide can greatly stimulate population growth and alter expression of genes involved in stress response and development. However, we still have a relatively poor understanding of the ecological and evolutionary significance of insecticide-induced hormesis for insects. The long-term goal of the research program is to understand the adaptive significance and potential practical applications of hormetic stress responses in insects. This will serve as a centerpiece for the following short-term objectives/questions:

极低剂量的杀虫剂对昆虫有刺激作用。这种两相毒理现象，即一种化学物质在高剂量时可能是有毒的，但在低剂量时是刺激的，这种现象被称为“兴奋效应”。我们之前的研究表明，昆虫暴露在中等剂量的杀虫剂下可以极大地刺激种群增长，并改变参与应激反应和发育的基因的表达。然而，我们对杀虫剂诱导的昆虫兴奋的生态和进化意义的了解仍然相对较少。该研究计划的长期目标是了解昆虫节律应激反应的适应意义和潜在的实际应用。这将作为以下短期目标/问题的核心：