Molelcular Dissection of Ectodomain Shedding: Biology of BACE1 and Other Sheddases.

点击翻译按钮获取中文摘要

Currently, our model sheddase is BACE1, a type I transmembrane protein related to the pepsin and retroviral aspartic acid protease families. A single transmembrane sequence (TMS) links the ectodomain to the cytosolic tail, constituting a unique feature amongst aspartic proteases. Recent literature has revealed that BACE1 can cleave a more diverse array of substrates than anticipated. Since our recent findings have also revealed that metal ions can interact with BACE1, we hypothesize that copper modulates its physiological properties.