Bioinorganic chemistry of metalloproteins and synthetic analogues

金属蛋白和合成类似物的生物无机化学

• 批准号: RGPIN-2015-05819
• 负责人: Stillman, Martin
• 金额: $ 4.3万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590659
• 关键词: Bioinorganic; chemistry; metalloproteins; synthetic; analogues

The research to be carried out concerns the biological functionality of metals and their host molecules, and the prediction of properties for technological applications of synthetic analogues. Metals in biological systems control all life, in many cases by binding to the donor atoms of amino acids in the peptide chains of proteins. Metal ions also bind to specific chelators that then activate proteins for function. Metals are the active site for catalysis, maintain cellular ionic strength, form structural materials and control protein folding through their coordination to amino acids. While all organisms require a variety of metals, the supply and availability of these metal ions must be regulated in the cell to avoid deficiency, leading to functional stress, while an excess leads to toxicity.

将开展的研究涉及金属及其宿主分子的生物功能，以及合成类似物的技术应用性质的预测。生物系统中的金属控制着所有的生命，在许多情况下是通过与蛋白质多肽链中氨基酸的供体原子结合来控制的。金属离子还与特定的螯合剂结合，然后激活蛋白质发挥功能。金属是催化的活性部位，维持细胞离子强度，形成结构材料，通过与氨基酸配位控制蛋白质折叠。虽然所有生物都需要多种金属，但这些金属离子的供应和可用性必须在细胞内进行调节，以避免缺乏导致功能应激，而过量则导致毒性。