Recruitment of a Bioinorganic Chemistry Faculty Member

描述（由申请人提供）：金属中心是基本生命过程（如呼吸、光合作用以及碳、氢、氮和硫代谢）中必不可少的和丰富的辅因子，金属蛋白的数量和多样性以及金属中心的生物学作用继续有增无减。金属中心在生物学中的功能包括运输小分子如氧和一氧化氮，介导电子传递和自由基产生，结合和激活各种金属酶中的底物，以及响应于金属、氧或一氧化氮浓度和氧化应激条件在细胞水平调节生物过程。此外，生命过程对金属离子的依赖，在升高的浓度下对细胞可能是有毒的，这导致了用于金属辅因子的储存、运输、递送和生物发生的复杂系统。在过去的30年里，随着研究工作的不断深入，人们对金属中心在生物过程和人类健康中的作用和组装的理解大大加快，研究工作涵盖了从遗传学和微生物学到化学和生物物理学的一系列学科，为在细胞和分子水平上理解生命过程和人类疾病提供了巨大的潜力。为此，格鲁吉亚大学的金属酶中心（CMS）成立于1986年，旨在促进金属生物化学的最先进的多学科研究和培训。本建议的目的是招聘一名对金属生物化学有研究兴趣的终身助理教授。该职位将设在化学系，并将利用与金属酶研究中心相关的设施和专业知识。我们预计，新聘人员将加强和扩大目前的专业知识，在生物医学重要领域的金属生物化学研究，涉及金属稳态，金属毒性，组装中心，和机械金属酶学。

DESCRIPTION (provided by applicant): Metal centers are essential and abundant cofactors in fundamental life processes such as respiration, photosynthesis, and carbon, hydrogen, nitrogen and sulfur metabolism and the number and diversity of metalloproteins and the biological roles for metal centers continue to proliferate unabated. The functons of metal centers in biology include transporting small molecules such as oxygen and nitric oxide, mediating electron transport and radical generation, binding and activating substrates in wide variety of metalloenzymes, and regulating biological processes at the cellular level in response to metal, oxygen or nitric oxide concentrations and oxidative stress conditions. Moreover the reliance of life processes on metal ions that can be toxic to the cell at elevated concentrations has resulted in elaborate systems for the storage, transport, delivery, and biogenesis of metallocofactors. Progress in understanding the roles and assembly of metal centers in biological processes and in human health have greatly accelerated over the past 30 years with research efforts spanning a range of disciplines from genetics and microbiology to chemistry and biophysics that offer enormous potential for understanding life processes and human diseases at both the cellular and molecular levels. To this end, the Center for Metalloenzyme (CMS) at the University of Georgia was founded in 1986 in order to foster state-of-the-art multidisciplinary research and training in metallobiochemistry. The objective of this proposal is to recruit a tenure-track Assistant Professor with research interests in metallobiochemistry. The position would be located in the Chemistry Department and would utilize the facilities and expertise associated with the Center for Metalloenzyme Studies. We anticipate that the new hire will enhance and extend current expertise in biomedically important areas of metallobiochemistry research involving metal homeostasis, metal toxicity, metallocenter assembly, and mechanistic metalloenzymology.