The cellular basis of morphogenetic differences between ectoderm and mesoderm

外胚层和中胚层形态发生差异的细胞基础

• 批准号: RGPIN-2015-05840
• 负责人: Fagotto, Francois
• 金额: $ 2.62万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590674
• 关键词: cellular; basis; morphogenetic; differences; between

To build an adult organism, different parts of embryos progressively develop distinct properties. One of the most important differences is between the cell populations that will build “barriers”, such as the skin, the gut wall, or the blood vessels, and the cells that will migrate more in isolation to populate the space between these barriers , where they will later from for example muscles, tendons, or joins. Two major aspects of these different cells correspond cell adhesion (much higher in the first group) and to migration (much higher in the second group).

为了形成一个成年生物，胚胎的不同部分逐渐发展出不同的特性。最重要的区别之一是，会形成“屏障”的细胞群，如皮肤、肠壁或血管，和会更多地孤立地迁移到这些屏障之间的细胞群之间，这些细胞后来会从肌肉、肌腱或关节中迁移出来。这些不同细胞的两个主要方面对应于细胞粘附性（第一组高得多）和迁移性（第二组高得多）。