Stress field within biological tissues from multiparametric Magnetic Resonance Imaging

生物组织的重塑在很大程度上是由于细胞所承受的机械应力。在许多疾病中，组织机械损伤与扰乱的机械应力分布有关，这种分布触发了生物变化。这些生物变化产生了结构变化，进而改变了机械性能和应力分布，导致了一个“恶性循环”。我相信，评估生物组织内的机械应力是理解人类基本过程的基石，并将使我们能够制定新的战略来打破这种“恶性循环”。我的研究计划的长期目标是提供新的诊断成像和建模技术，以便对肌肉骨骼或心脏组织内的机械应力进行稳健的在体评估，从而进一步预测人体组织的降解和再生。

Biological tissues remodeling is largely due to the mechanical stresses withstood by the cells. In many diseases, tissue mechanical damage is associated to a perturbed mechanical stress distribution that triggers biological changes. These biological changes produce structural changes that in turn modify the mechanical properties and stress distribution, resulting in a “vicious cycle”. I believe that the evaluation of the mechanical stresses within biological tissues is a cornerstone in understanding of fundamental processes in humans and would enable defining new strategies to break this “vicious cycle”. The long-term objective of my research program is to provide new diagnostic imaging and modeling technologies for the robust in vivo mechanical stresses evaluation within musculoskeletal or cardiac tissues for further prediction of human tissues degradation and regeneration.