Development of Functional Peptide Nanostructures

功能性肽纳米结构的开发

• 批准号: 197473-2012
• 负责人: Voyer, Normand
• 金额: $ 4.01万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593737
• 关键词: Development; Functional; Peptide; Nanostructures

Inspired by the properties of natural proteins, our group is working to construct artificial molecular systems of nanometer dimension designed to perform specific tasks with unprecedented level of efficiency. Even though great successes have been achieved using creative approaches, lot more work is necessary to delineate the molecular guidelines to predict and understand the functions of artificial nanoscale systems and, most importantly, to exploit them into routine practical applications. The unifying theme of our program is the construction of unique nanoscale molecular architectures with tailor-made functions exploiting the power of combining chemical synthesis with the advantages of peptidic structures. More specifically, this proposal describes three research areas where we will invest our efforts; 1) the use of artificial ion channels for the development of real-time sensing devices for biologically relevant analytes, 2) the development of selective nanochemotherapeutics, and 3) the discovery of efficient antimicrobials based on crown peptide nanostructures.

受天然蛋白质特性的启发，我们的团队正在致力于构建纳米尺寸的人工分子系统，旨在以前所未有的效率执行特定任务。尽管使用创造性方法已经取得了巨大的成功，但仍需要做更多的工作来描绘分子指南来预测和理解人造纳米级系统的功能，最重要的是，将它们用于常规的实际应用。我们项目的统一主题是利用化学合成与肽结构优势相结合的力量，构建具有定制功能的独特纳米级分子结构。更具体地说，该提案描述了我们将投入精力的三个研究领域； 1) 使用人工离子通道开发生物相关分析物的实时传感装置，2) 开发选择性纳米化疗药物，3) 发现基于冠肽纳米结构的高效抗菌剂。