Deciphering cellular mechanisms regulating neuromuscular development

破译调节神经肌肉发育的细胞机制

• 批准号: 238826-2012
• 负责人: Rafuse, Victor
• 金额: $ 3.5万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=594192
• 关键词: Deciphering; cellular; mechanisms; regulating; neuromuscular

Motoneurons innervate their appropriate muscle targets with remarkable precision during embryogenesis. To accomplish this task, the growth cone must make numerous pathfinding decisions as it grows to its correct target. Most decisions can be described as growing towards a desired guidance cue or away from a repulsive one. A directional decision shared by all developing motor axons is that to extend an axon out of the spinal cord. The last decision is more refined and involves determining whether to synapse with a fast or slow contracting muscle fibre. Ultimately, all guidance cues activate distinct intracellular signaling pathways that trigger asymmetrical changes in the growth cone causing it to turn towards or away from a cue.

运动神经元在胚胎发育过程中以非常精确的方式支配其适当的肌肉靶点。为了完成这个任务，生长锥必须在向正确目标生长的过程中做出许多寻路决策。大多数决定可以被描述为朝着一个期望的指导线索或远离一个排斥的线索发展。所有发育中的运动轴突都有一个共同的方向性决定，那就是将轴突伸出脊髓。最后一个决定是更精确的，包括确定是否与快速或缓慢收缩的肌肉纤维突触。最终，所有的引导线索激活不同的细胞内信号传导途径，触发生长锥的不对称变化，使其转向或远离线索。