Adaptive strategies of the vertebrate heart to environmental stress; regulation of function and morphology

脊椎动物心脏对环境应激的适应性策略；

• 批准号: 326949-2012
• 负责人: Gillis, Todd
• 金额: $ 2.91万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595169
• 关键词: Adaptive; strategies; vertebrate; heart; environmental

The vertebrate heart is incredibly adaptable. An example of this is the rapid increase in the rate and strength of cardiac contraction that occurs when an animal gets startled. Another example is the increase in heart size that occurs in response to prolonged periods of exercise training. These changes in heart function and heart morphology increase the rate at which blood can be delivered to the tissues and enable a higher rate of physical activity. The heart can also undergo maladaptive changes following cardiac injury or disease. Here scar tissue forms in the heart and the amount of muscle decreases resulting in a weakened heart with impaired function. While the above adaptive and maladaptive changes have been well described at the organ level there is less known of the cellular pathways responsible for initiating and regulating them.

脊椎动物的心脏具有令人难以置信的适应性。这方面的一个例子是，当动物受到惊吓时，心脏收缩的速度和强度会迅速增加。另一个例子是长时间的运动训练导致心脏大小的增加。心脏功能和心脏形态的这些变化增加了血液输送到组织的速度，从而提高了身体活动的速度。心脏也可能在心脏损伤或疾病后发生不适应变化。在这里，疤痕组织在心脏中形成，肌肉量减少，导致心脏功能受损。虽然上述适应和不适应的变化已经在器官水平上得到了很好的描述，但对负责启动和调节它们的细胞途径知之甚少。