Mechanisms of change, cellular responses of the fish heart to physiological stress

鱼心脏对生理应激的变化机制、细胞反应

• 批准号: RGPIN-2017-06292
• 负责人: Gillis, Todd
• 金额: $ 2.84万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630485
• 关键词: Mechanisms; change; cellular; responses; fish

A powerful heart is essential to supporting life. Interesting, the vertebrate heart is able to change both its form and function to meet the changing requirements of the animal. For example, exercise training will cause the heart to increase in size and pump more blood per beat. This change to the heart increases the rate at which blood can be delivered to the tissues and enables a higher rate of physical activity. The heart can also undergo maladaptive changes following cardiac injury or disease. Here, scar tissue forms in the heart and the amount of muscle decreases resulting in a weakened heart with impaired function. While the above adaptive and maladaptive changes have been well described at the organ level, there is less known of the cellular pathways responsible for initiating and regulating them.

强大的心脏是维持生命的关键。有趣的是，脊椎动物的心脏能够改变其形式和功能，以满足动物不断变化的需求。例如，运动训练会导致心脏尺寸增加，每次跳动泵出更多的血液。心脏的这种变化增加了血液输送到组织的速率，并使身体活动的速率更高。心脏也可能在心脏损伤或疾病后发生适应不良的变化。在这里，疤痕组织在心脏中形成，肌肉数量减少，导致心脏功能受损。虽然上述适应性和适应不良的变化已经在器官水平上得到了很好的描述，但对启动和调节它们的细胞途径知之甚少。