Natural Product Biosynthesis in Lichen and Other Fungi

地衣和其他真菌中的天然产物生物合成

• 批准号: 341607-2012
• 负责人: Sorensen, John
• 金额: $ 2.55万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595438
• 关键词: Natural; Product; Biosynthesis; Lichen; Other

The identification of novel biologically active natural products is key to the long-term development of new clinical treatments for infections and disease. The Sorensen Natural Products Laboratory at the University of Manitoba is examining the production of natural products by unique strains of lichen and fungi from Northern Manitoba. Have started to develop a detailed understanding of the biosynthesis of the antibacterial and antifungal lichen natural product usnic acid. We will use molecular biology techniques to identify the genes, and thereby the enzymes, that are involved in the biosynthesis of usnic acid. This proposal describes how we will use this knowledge to produce natural product analogues with improved biological activity.

新型生物活性天然产物的鉴定是感染和疾病新临床治疗长期开发的关键。曼尼托巴大学索伦森天然产品实验室正在研究利用来自曼尼托巴北部的独特地衣和真菌菌株生产天然产品。已开始详细了解抗菌和抗真菌地衣天然产物松萝酸的生物合成。我们将使用分子生物学技术来鉴定参与松萝酸生物合成的基因，从而鉴定酶。该提案描述了我们将如何利用这些知识来生产具有改进的生物活性的天然产物类似物。