Development of a Procedure for the Extraction and Purification of Rutin from Buckwheat Forage: A Laboratory Study Required for the Industrial Production of Rutin

开发从荞麦饲料中提取和纯化芦丁的方法：工业生产芦丁所需的实验室研究

• 批准号: 515719-2017
• 负责人: Sorensen, John
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=640717
• 关键词: Development; Procedure; Extraction; Purification; Rutin

All Natural Nutritional Products (ANNP) Inc. is a research-based Natural Health Product company thatproduces and markets high quality nutraceutical supplements licensed by Health Canada. The two principals ofthe company are Dr. Ronald R. Marquardt and Dr. S. Li. ANNP, in a new venture, is interested in bringing bulkquantities of two high-value and widely used natural products, rutin and its aglycone, quercetin, to thenutraceuticals market. These natural products can be extracted from buckwheat forage. It will be necessary tofirst demonstrate that the two products can be economically produced in a laboratory-based study as proposedin the Engage Grant application. Dr. John Sorensen, Associate Professor in the Department of Chemistry,University of Manitoba, will develop a study designed to optimize the extraction, isolation and purification ofrutin from buckwheat and then the hydrolytic production of quercetin from rutin. The Sorensen lab hasextensive experience in Natural Products Chemistry, and has a well-equipped laboratory and the support staffcapable of carrying out all aspects of the proposed research. It is anticipated that the project will result in thedevelopment of simple, innovative, unique and inexpenseive method for the production of the two products.The optimized procedures will then be scaled up in a pilot plant study followed by the industrial production ofthe two products in a state-of-the-art manufacturing facility in Manitoba. Dr. Sorensen's research will enableANNP to competitively and profitably produce the two high value nutraceuticals from a locally produced crop.The research will form the basis for establishing a new and profitable industry in Canada.

全天然营养产品（ANNP）公司是一家以研究为基础的天然健康产品公司，生产和销售由加拿大卫生部许可的高品质营养补充剂。该公司的两位主要负责人是罗纳德博士。马夸特和S.李ANNP，在一个新的合资企业，有兴趣把大量的两个高价值和广泛使用的天然产品，芦丁和它的糖苷配基，槲皮素，到thenutraceuticals市场。这些天然产物可以从荞麦饲料中提取。这将是必要的，首先证明这两种产品可以经济地生产在一个实验室为基础的研究中提出的参与赠款申请。马尼托巴大学化学系副教授John Sorensen博士将开展一项研究，旨在优化从荞麦中提取、分离和纯化芦丁，然后从芦丁水解生产槲皮素。Sorensen实验室在天然产物化学方面拥有丰富的经验，并拥有设备齐全的实验室和支持人员，能够开展拟议研究的各个方面。预计该项目将开发出简单、创新、独特和廉价的生产这两种产品的方法。优化后的程序将在中试工厂研究中扩大规模，然后在马尼托巴的一个最先进的生产设施中进行这两种产品的工业生产。Sorensen博士的研究将使ANNP能够从当地生产的作物中生产出具有竞争力和盈利能力的两种高价值营养品。该研究将为在加拿大建立一个新的盈利行业奠定基础。