Connecting genes to molecules: Natural product biosynthesis in lichen

将基因与分子连接：地衣中的天然产物生物合成

• 批准号: RGPIN-2017-04958
• 负责人: Sorensen, John
• 金额: $ 3.28万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632752
• 关键词: Connecting; genes; molecules; Natural; product

We achieve this by linking the genes we discover in the lichen genome to the biosynthesis of small biologically active molecules. Usnic acid, one of the most prevalent natural products produced by lichen fungi, has displayed biological activity ranging from antibiotic to anticancer as well as disrupting biofilm formation. However the other natural products produced by lichen fungi have been explored to a much lesser extent. This program may lead to the discovery of the next transformative natural product, like penicillin.

我们通过将我们在地衣基因组中发现的基因与生物活性小分子的生物合成联系起来来实现这一点。松萝酸是地衣真菌产生的最普遍的天然产物之一，具有从抗生素到抗癌以及破坏生物膜形成的生物活性。然而，地衣真菌产生的其他天然产物的探索程度要小得多。这个项目可能会导致下一个革命性的自然产品的发现，比如青霉素。