"Understanding, engineering and exploiting protein self-assembly."

“理解、设计和利用蛋白质自组装。”

• 批准号: 342034-2012
• 负责人: Rainey, Jan
• 金额: $ 2.04万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=595553
• 关键词: Understanding; engineering; exploiting; protein; self

Fibre formation by proteins is required in many biological situations. Despite this fact, the way that proteins reproducibly form fibres with specific size, shape and chemical features remains elusive. It is likely, in fact, that nature has evolved a number of different approaches to answer this problem. This Discovery Grant will build understanding of the transformation from isolated proteins soluble in water to fibrillar forms with dramatically different properties. By doing so, fundamental insight into these critical biological entities will be developed and we will be able to tweak and optimize protein fibrils for new purposes. Two specific types of protein fibre are targeted in this Discovery Grant.

许多生物情况都需要蛋白质形成纤维。尽管如此，蛋白质可再生地形成具有特定尺寸、形状和化学特征的纤维的方式仍然难以捉摸。事实上，很可能大自然已经进化出许多不同的方法来回答这个问题。这项发现基金将建立对从可溶于水的分离蛋白质到具有显著不同性质的纤维状形式的转变的理解。通过这样做，对这些关键生物实体的基本见解将得到发展，我们将能够为新的目的调整和优化蛋白质原纤维。两种特定类型的蛋白质纤维是这项发现基金的目标。