Synthesis of next-generation UV indicators for sun safety applications

Suncayr目前正在研发一种基于入射紫外线辐射的颜色变化指示器，当用户的防晒霜不再有效时，它会告诉用户。Suncayr目前正在使用一种紫外线响应分子，当暴露在阳光的紫外线辐射下时，这种分子会从无色变成紫色，向用户表明他们正在受到有害的紫外线的影响。 Suncayr正在寻找其原始化合物的下一代衍生物，这些衍生物将根据到达皮肤的入射紫外线辐射量表现出不同的响应因子。例如，这种分子可能是足够可调的，使Suncayr能够开发出在不同SPF保护水平（如SPF 2，4或8）下显示基于颜色的警告指示的产品。如果UV指示剂化合物可以衍生化以允许这种不同的性质，则将导致改进的指示剂，其可针对不同的最终用户定制。 Suncayr缺乏合成专业知识和设施，无法对其紫外线响应染料进行必要的修改。通过与墨菲实验室合作，他们将获得进行这项基础研究所需的人员、专业知识、设施和设备。Murphy实验室将使用分子建模和化学合成的互补策略来指导他们的工作，这将产生一个小型的衍生物库供Suncayr测试。有希望的候选人将在更大的规模上进行合成，为Suncayr提供足够的材料来进行材料性能分析。

Suncayr is currently in the research and development phase of creating a colour change indicator based on incident UV radiation that will tell the user when their sunscreen is no longer effective. Suncayr is currently using a UV responsive molecule that will change from colourless to purple when exposed to the UV radiation of sunlight, indicating to the user that they are being subject to harmful UV rays. Suncayr is looking for next-generation derivatives of their original compound that will exhibit different response factors depending on the amount of incident UV radiation reaching the skin. For example, this molecule might be sufficiently tunable to enable Suncayr to develop products that will exhibit a colour-based warning indication at differing SPF protection levels (such as SPF 2, 4 or 8). If the UV indicator compound can be derivatized to permit such differing properties, it will result in improved indicators that are customizable for different end users. Suncayr lacks the synthetic expertise and facility to make the necessary alterations to their UV responsive dye. By collaborating with the Murphy laboratory, they will gain access to the required personnel, expertise, facilities and equipment necessary to undertake this fundamental research. The Murphy lab will use the complementary strategies of molecular modeling and chemical synthesis to guide their work, which will generate a small library of derivatives for Suncayr to test. Promising candidates will be synthesized on larger scale to provide Suncayr with sufficient materials to carry out their materials performance analyses.